Literature DB >> 15214798

Inhibition of cytokine production by hymenialdisine derivatives.

Vasudha Sharma1, Theresa A Lansdell, Guangyi Jin, Jetze J Tepe.   

Abstract

We describe herein the synthesis and biological activity of two indoloazepines that are structurally related to the marine sponge metabolite hymenialdisine. The natural product hymenialdisine was found to be a potent inhibitor of interleukin-2 (IC(50) = 2.4 microM) and tumor necrosis factor alpha (IC(50) = 1.4 microM) production. One of the hymenialdisine derived indoloazepines was found to also inhibit interleukin-2 (IC(50) = 3.5 microM) and tumor necrosis factor alpha (IC(50) = 8.2 microM) production.

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Year:  2004        PMID： 15214798     DOI： 10.1021/jm040013d

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  6 in total

1.  Pityriazepin and other potent AhR ligands isolated from Malassezia furfur yeast.

Authors:  Nikitia Mexia; Georgios Gaitanis; Aristea Velegraki; Anatoly Soshilov; Michael S Denison; Prokopios Magiatis
Journal:  Arch Biochem Biophys       Date:  2015-02-24       Impact factor: 4.013

2.  Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3.

Authors:  Mahboubeh S Noori; Pooja M Bhatt; Maria C Courreges; Davoud Ghazanfari; Chaz Cuckler; Crina M Orac; Mark C McMills; Frank L Schwartz; Sudhir P Deosarkar; Stephen C Bergmeier; Kelly D McCall; Douglas J Goetz
Journal:  Am J Physiol Cell Physiol       Date:  2019-09-25       Impact factor: 4.249

3.  Evaluation of the Anti-Inflammatory, Antioxidant and Immunomodulatory Effects of the Organic Extract of the Red Sea Marine Sponge Xestospongia testudinaria against Carrageenan Induced Rat Paw Inflammation.

Authors:  Nagla A El-Shitany; Lamiaa A Shaala; Aymn T Abbas; Umama A Abdel-Dayem; Esam I Azhar; Soad S Ali; Rob W M van Soest; Diaa T A Youssef
Journal:  PLoS One       Date:  2015-09-30       Impact factor: 3.240

Review 4.  Promising bioactive compounds from the marine environment and their potential effects on various diseases.

Authors:  Akash Karthikeyan; Abey Joseph; Baiju G Nair
Journal:  J Genet Eng Biotechnol       Date:  2022-01-26

5.  10Z‑Hymenialdisine inhibits angiogenesis by suppressing NF‑κB activation in pancreatic cancer cell lines.

Authors:  Goro Ueda; Yoichi Matsuo; Hiromichi Murase; Yoshinaga Aoyama; Tomokatsu Kato; Kan Omi; Yuichi Hayashi; Hiroyuki Imafuji; Kenta Saito; Ken Tsuboi; Mamoru Morimoto; Ryo Ogawa; Hiroki Takahashi; Akira Mitsui; Masahiro Kimura; Shuji Takiguchi
Journal:  Oncol Rep       Date:  2022-01-11       Impact factor: 3.906

6.  Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays.

Authors:  Jing Xiang; Hongbo Yang; Chao Che; Haixia Zou; Hanshuo Yang; Yuquan Wei; Junmin Quan; Hui Zhang; Zhen Yang; Shuo Lin
Journal:  PLoS One       Date:  2009-02-05       Impact factor: 3.240
  6 in total

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