| Literature DB >> 15214775 |
Russell G Dushin1, Ting-Zhong Wang, Phaik-Eng Sum, Haiyin He, Alan G Sutherland, Joseph S Ashcroft, Edmund I Graziani, Frank E Koehn, Patricia A Bradford, Peter J Petersen, Karen L Wheless, David How, Nancy Torres, Eileen B Lenoy, William J Weiss, Stanley A Lang, Steven J Projan, David M Shlaes, Tarek S Mansour.
Abstract
The effect of introducing hydrophobic groups onto the disaccharide portion of the mannopeptimycins has been examined. Under acid-catalyzed conditions dimethyl acetals and ketals react on the terminal mannose of the disaccharide moiety of mannopeptimycin-alpha and the cyclohexylalanyl analogue 2. The preferentially formed monofunctionalized 4,6-acetals and -ketals display potent antibacterial activities against Gram-positive microorganisms, including MRSA, PRSP, and VRE pathogens.Entities:
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Year: 2004 PMID： 15214775 DOI： 10.1021/jm049765y
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446