| Literature DB >> 15214774 |
Fabio C Tucci1, Yun-Fei Zhu, Zhiqiang Guo, Timothy D Gross, Patrick J Connors, Yinghong Gao, Martin W Rowbottom, R Scott Struthers, Greg J Reinhart, Qiu Xie, Ta Kung Chen, Haig Bozigian, Anne L Killam Bonneville, Andrew Fisher, Liping Jin, John Saunders, Chen Chen.
Abstract
Uracils possessing N-3 side chains derived from various amino alcohols were designed and synthesized as potent human gonadotropin releasing hormone receptor antagonists. The compounds herein presented displayed superior metabolic stability than their predecessor molecules. Selected compounds from this series featured good oral bioavailability in mice and cynomolgus monkeys.Entities:
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Year: 2004 PMID： 15214774 DOI： 10.1021/jm049791w
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446