Literature DB >> 15212972

CART peptide increases the mesolimbic dopaminergic neuronal activity: a microdialysis study.

Shu-Chuan Yang1, Jenn-Tser Pan, Hui-Yun Li.   

Abstract

The effects of cocaine-and amphetamine-regulated transcript (CART) peptide on extracellular concentrations of dopamine metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in the shell region of the nucleus accumbens (AcbSh) were determined by microdialysis in conscious rats. Intracerebroventricular injections of various doses (0.1-5 microg/5 microl/rat) of CART(55-102) elicited dose-dependent increases of extracellular DOPAC and HVA concentration in the AcbSh, suggesting that CART(55-102) peptide has a psychostimulant-like effect via activation of the mesolimbic dopaminergic system.

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Year:  2004        PMID： 15212972     DOI： 10.1016/j.ejphar.2004.05.018

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  12 in total

1.  Reduced ethanol consumption and preference in cocaine- and amphetamine-regulated transcript (CART) knockout mice.

Authors:  Armando G Salinas; Chinh T Q Nguyen; Dara Ahmadi-Tehrani; Richard A Morrisett
Journal:  Addict Biol       Date:  2012-07-24       Impact factor: 4.280

Review 2.  Cocaine- and amphetamine-regulated transcript peptides play a role in drug abuse and are potential therapeutic targets.

Authors:  Michael J Kuhar; Jason N Jaworski; George W Hubert; Kelly B Philpot; Geraldina Dominguez
Journal:  AAPS J       Date:  2005-09-02       Impact factor: 4.009

3.  Wake promoting effects of cocaine and amphetamine-regulated transcript (CART).

Authors:  Glenda L Keating; Michael J Kuhar; Donald L Bliwise; David B Rye
Journal:  Neuropeptides       Date:  2010-02-08       Impact factor: 3.286

4.  CART peptide following social novelty in the prairie vole (Microtus ochrogaster).

Authors:  Caroline M Hostetler; Alex S Kowalczyk; Luana L Griffin; Karen L Bales
Journal:  Brain Res       Date:  2011-07-24       Impact factor: 3.252

5.  The effects of amphetamine injections on feeding behavior and the brain expression of orexin, CART, tyrosine hydroxylase (TH) and thyrotropin releasing hormone (TRH) in goldfish (Carassius auratus).

Authors:  Hélène Volkoff
Journal:  Fish Physiol Biochem       Date:  2012-12-11       Impact factor: 2.794

6.  Intra-VTA CART 55-102 reduces the locomotor effect of systemic cocaine in rats: an isobolographic analysis.

Authors:  Jason N Jaworski; Heather L Kimmel; Darlene A Mitrano; Ronald J Tallarida; Michael J Kuhar
Journal:  Neuropeptides       Date:  2007-02-07       Impact factor: 3.286

7.  Intraperitoneal Administration of CART 55-102 Inhibits Psychostimulant-Induced Locomotion.

Authors:  Martin O Job; Michael J Kuhar
Journal:  J Drug Alcohol Res       Date:  2012-01-01

8.  Effect of desipramine and citalopram treatment on forced swimming test-induced changes in cocaine- and amphetamine-regulated transcript (CART) immunoreactivity in mice.

Authors:  Sung Chung; Hee Jeong Kim; Hyun Ju Kim; Sun Hye Choi; Jin Wook Kim; Jeong Min Kim; Kyung Ho Shin
Journal:  Neurochem Res       Date:  2014-04-20       Impact factor: 3.996

9.  Genetic regulation of hypothalamic cocaine and amphetamine-regulated transcript (CART) in BxD inbred mice.

Authors:  Ericka M Boone; Brian W Hawks; Wei Li; Steven J Garlow
Journal:  Brain Res       Date:  2007-12-14       Impact factor: 3.252

10.  CART peptides increase 5-hydroxytryptamine in the dorsal raphe and nucleus accumbens of freely behaving rats.

Authors:  Zhiyuan Ma; Elliot Pearson; Rui Tao
Journal:  Neurosci Lett       Date:  2007-02-23       Impact factor: 3.046
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