| Literature DB >> 15212512 |
Kosuke Namba1, Hyuk-Sang Jun, Yoshito Kishi.
Abstract
A simple device consisting of two ion-exchange columns, two alumina-based filters, and a pump (Figure 1) was assembled to form the C8-C14 polycyclic ring system present in the halichondrin B class of marine natural products. The effectiveness of this device was tested for three substrates. In each case, the desired polycyclic ketal 3, 5, or 7 was obtained almost quantitatively in a single operation.Entities:
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Year: 2004 PMID： 15212512 DOI： 10.1021/ja047826b
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419