Literature DB >> 1521142

Repeated stress enhances vasopressin synthesis in corticotropin releasing factor neurons in the paraventricular nucleus.

D C de Goeij1, D Jezova, F J Tilders.   

Abstract

The effect of repeated stress on corticotropin-releasing factor (CRF) and vasopressin (AVP) synthesis in parvocellular neurons of the paraventricular nucleus (PVN) was studied by means of double label immunocytochemistry. Once daily immobilization of male rats for 16 days leads to a 75% increase in the number of CRF immunoreactive neurons, but a 5-fold elevation in the number of AVP containing CRF cell bodies. These results demonstrate that repeated stress activates AVP synthesis in CRF neurons.

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Year:  1992        PMID： 1521142     DOI： 10.1016/0006-8993(92)90552-k

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  23 in total

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