BACKGROUND: Differences in clarithromycin disposition and the resulting changes in bacterial density were studied using mouse lung and thigh infection models. METHODS: Clarithromycin activity was evaluated against seven Streptococcus pneumoniae isolates with efflux-mediated resistance in both murine lung and thigh infection models. Intrapulmonary disposition of clarithromycin was also studied. RESULTS: Consistent bacterial kill was observed in the lung model, whereas no drug effect was observed in the thigh model. CONCLUSION: These differences in bacterial density were supported by high concentrations observed in epithelial lining fluid as compared to serum. Copyright 2004 S. Karger AG, Basel
BACKGROUND: Differences in clarithromycin disposition and the resulting changes in bacterial density were studied using mouse lung and thigh infection models. METHODS:Clarithromycin activity was evaluated against seven Streptococcus pneumoniae isolates with efflux-mediated resistance in both murine lung and thigh infection models. Intrapulmonary disposition of clarithromycin was also studied. RESULTS: Consistent bacterial kill was observed in the lung model, whereas no drug effect was observed in the thigh model. CONCLUSION: These differences in bacterial density were supported by high concentrations observed in epithelial lining fluid as compared to serum. Copyright 2004 S. Karger AG, Basel
Authors: Pamela R Tessier; Holly M Mattoes; Prachi K Dandekar; Charles H Nightingale; David P Nicolau Journal: Antimicrob Agents Chemother Date: 2005-01 Impact factor: 5.191