| Literature DB >> 15210908 |
J M Partridge1, S J M Weatherby, J A Woolmore, D J Highland, A A Fryer, C L A Mann, M D Boggild, W E R Ollier, R C Strange, C P Hawkins.
Abstract
Multiple sclerosis (MS) risk is determined by environment and genes. The authors investigated in 419 cases and 422 controls if polymorphism in the vitamin D receptor (VDR), melanocortin-1 receptor (MC1R), and tyrosinase (TYR) genes is linked with MS risk and outcome. VDR ff was associated with reduced (odds ratio [OR] = 0.59) and MC1R His294-encoding alleles with increased (OR = 2.21) risk. MC1R Glu84/Glu84 was linked with disability (OR = 5.65). These preliminary data suggest a role for these genes in MS pathogenesis.Entities:
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Year: 2004 PMID： 15210908 DOI： 10.1212/wnl.62.12.2323
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910