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Literature DB >> 1521040

Smoking influences the atherogenic potential of low-density lipoprotein.

E Scheffler¹, E Wiest, J Woehrle, I Otto, I Schulz, L Huber, R Ziegler, H A Dresel.

Abstract

The possible influence of smoking on the low-density lipoprotein (LDL) and its biological activity was investigated. Plasma LDL was prepared from healthy male smokers and nonsmokers, and oxidized with Cu (II) as prooxidant. Oxidized LDL from smokers generated significantly more lipid peroxidation products, so-called thiobarbituric acid reactive substances (TBARS), when compared to oxidized nonsmoker LDL. Analysis of vitamin E levels in LDL obtained from both smokers and nonsmokers revealed that the vitamin E content of smoker LDL was significantly less than that of nonsmoker LDL. The amounts of cholesteryl esters formed in cultured P388. D.1 macrophages were greater in the presence of smoker LDL than with nonsmoker LDL. The data suggest that some of the proatherogenic effects of smoking may be related to oxidative modification of LDL and alteration of its biological activity.

Entities: Chemical

Mesh：

Substances：

Year: 1992 PMID： 1521040 DOI： 10.1007/bf00184660

Source DB: PubMed Journal: Clin Investig ISSN： 0941-0198

44 in total

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Authors: A J HAAGEN-SMIT; M F BRUNELLE; J HARA
Journal: AMA Arch Ind Health Date: 1959-11

Review 2. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.

Authors: D Steinberg; S Parthasarathy; T E Carew; J C Khoo; J L Witztum
Journal: N Engl J Med Date: 1989-04-06 Impact factor: 91.245

3. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

Authors: M T Quinn; S Parthasarathy; L G Fong; D Steinberg
Journal: Proc Natl Acad Sci U S A Date: 1987-05 Impact factor: 11.205

Review 4. Lipoproteins and atherosclerosis. A look back and a look ahead.

Authors: D Steinberg
Journal: Arteriosclerosis Date: 1983 Jul-Aug

Review 5. Role of biologically modified low-density lipoprotein in atherosclerosis.

Authors: T E Carew
Journal: Am J Cardiol Date: 1989-10-03 Impact factor: 2.778

6. Cholesteryl ester accumulation in macrophages incubated with low density lipoprotein pretreated with cigarette smoke extract.

Authors: M Yokode; T Kita; H Arai; C Kawai; S Narumiya; M Fujiwara
Journal: Proc Natl Acad Sci U S A Date: 1988-04 Impact factor: 11.205

7. Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells.

Authors: J W Heinecke; L Baker; H Rosen; A Chait
Journal: J Clin Invest Date: 1986-03 Impact factor: 14.808

8. Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.

Authors: A Faggiotto; R Ross; L Harker
Journal: Arteriosclerosis Date: 1984 Jul-Aug

9. Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes.

Authors: H Esterbauer; G Jürgens; O Quehenberger; E Koller
Journal: J Lipid Res Date: 1987-05 Impact factor: 5.922

10. Serum antibodies to oxidized low-density lipoprotein and ceroid in chronic periaortitis.

Authors: D V Parums; D L Brown; M J Mitchinson
Journal: Arch Pathol Lab Med Date: 1990-04 Impact factor: 5.534

13 in total

1. Smoking is associated with reduced serum paraoxonase, antioxidants and increased oxidative stress in normolipidaemic acute myocardial infarct patients.

Authors: Arun Kumar; Utpal Kumar Biswas
Journal: Heart Asia Date: 2011-01-01

Smoking influences the atherogenic potential of low-density lipoprotein.

1. Nitrogen oxide content of smokes from different types of tobacco.

Review 2. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.

3. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

Review 4. Lipoproteins and atherosclerosis. A look back and a look ahead.

Review 5. Role of biologically modified low-density lipoprotein in atherosclerosis.

6. Cholesteryl ester accumulation in macrophages incubated with low density lipoprotein pretreated with cigarette smoke extract.

7. Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells.

8. Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.

9. Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes.

10. Serum antibodies to oxidized low-density lipoprotein and ceroid in chronic periaortitis.

1. Smoking is associated with reduced serum paraoxonase, antioxidants and increased oxidative stress in normolipidaemic acute myocardial infarct patients.

2. Early atherosclerotic lesions in infancy: role of parental cigarette smoking.

3. Increased oxidative stress in infants exposed to passive smoking.

4. Maternal active or passive smoking causes oxidative stress in cord blood.

Review 5. The benefits of stopping smoking and the role of nicotine replacement therapy in older patients.

6. In vitro effect of nicotine and cotinine on the susceptibility of LDL oxidation and hemoglobin glycosylation.

7. Prevalence, awareness, treatment, and control of high LDL cholesterol in New York City, 2004.

8. Genetic polymorphisms in the Paraoxonase 1 gene and risk of ovarian epithelial carcinoma.

9. Effects of cigarette smoke, nicotine and cotinine on red blood cell hemolysis and their -SH capacity.

10. Cigarette smoking and serum bilirubin subtypes in healthy Korean men: the Korea Medical Institute study.