| Literature DB >> 15210178 |
Felix Loosli1, Filippo Del Bene, Rebecca Quiring, Martina Rembold, Juan-Ramon Martinez-Morales, Matthias Carl, Clemens Grabher, Caroline Iquel, Annette Krone, Beate Wittbrodt, Sylke Winkler, Takao Sasado, Chikako Morinaga, Hiroshi Suwa, Katsutoshi Niwa, Thorsten Henrich, Tomonori Deguchi, Yukihiro Hirose, Norimasa Iwanami, Sanae Kunimatsu, Masakazu Osakada, Tomomi Watanabe, Akihito Yasuoka, Hiroki Yoda, Christoph Winkler, Harun Elmasri, Hisato Kondoh, Makoto Furutani-Seiki, Joachim Wittbrodt.
Abstract
In a large scale mutagenesis screen of Medaka we identified 60 recessive zygotic mutations that affect retina development. Based on the onset and type of phenotypic abnormalities, the mutants were grouped into five categories: the first includes 11 mutants that are affected in neural plate and optic vesicle formation. The second group comprises 15 mutants that are impaired in optic vesicle growth. The third group includes 18 mutants that are affected in optic cup development. The fourth group contains 13 mutants with defects in retinal differentiation. 12 of these have smaller eyes, whereas one mutation results in enlarged eyes. The fifth group consists of three mutants with defects in retinal pigmentation. The collection of mutants will be used to address the molecular genetic mechanisms underlying vertebrate eye formation.Entities:
Mesh：
Year: 2004 PMID： 15210178 DOI： 10.1016/j.mod.2004.03.004
Source DB: PubMed Journal: Mech Dev ISSN： 0925-4773 Impact factor: 1.882