Literature DB >> 15210159

Synthesis of 1-(omega-aminoalkyl)naphthoindolediones with antiproliferative properties.

Andrey E Shchekotikhin1, Vladimir N Buyanov, Maria N Preobrazhenskaya.   

Abstract

The preparation and cytotoxic properties of 4,11-dihydroxynaphtho[2,3-f]indole-5,10-dione derivatives carrying N-aminoalkyl substituents are described. The N-aminobutylnaphthoindolediones obtained were studied in National Cancer Institute Screening Program and demonstrated high antiproliferative activity against 60 human cancer cell lines. All N-(4-aminobutyl) derivatives have higher potency than adriamycin or mitoxantrone against adriamycin selected multidrug resistant breast cancer cell line NCI/ADR.

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Year:  2004        PMID： 15210159     DOI： 10.1016/j.bmc.2004.04.042

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  3 in total

1.  Design, synthesis and biological evaluation of fused naphthofuro[3,2-c] quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma.

Authors:  Ashraf A Aly; Essmat M El-Sheref; Momtaz E M Bakheet; Mai A E Mourad; Stefan Bräse; Mahmoud A A Ibrahim; Martin Nieger; Boyan K Garvalov; Kevin N Dalby; Tamer S Kaoud
Journal:  Bioorg Chem       Date:  2018-10-23       Impact factor: 5.275

2.  6,9-Dimeth-oxy-3,4-dihydro-1H-1,4-oxazino[4,3-a]indol-1-one.

Authors:  Cristian O Salas; Ricardo A Tapia; Yolanda Prieto
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-01-12

3.  Induced production of antifungal naphthoquinones in the pitchers of the carnivorous plant Nepenthes khasiana.

Authors:  Haviva Eilenberg; Smadar Pnini-Cohen; Yocheved Rahamim; Edward Sionov; Esther Segal; Shmuel Carmeli; Aviah Zilberstein
Journal:  J Exp Bot       Date:  2009-12-16       Impact factor: 6.992
  3 in total

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