Literature DB >> 15210151

New chlorogenin hexasaccharide isolated from Agave fourcroydes with cytotoxic and cell cycle inhibitory activities.

Takashi Ohtsuki1, Takashi Koyano, Thaworn Kowithayakorn, Shinobu Sakai, Nobuo Kawahara, Yukihiro Goda, Naoto Yamaguchi, Masami Ishibashi.   

Abstract

A new chlorogenin hexasaccharide (1) was isolated from leaves of Agave fourcroydes (Agavaceae). The structure of the new saponin was elucidated as chlorogenin 3-O-[alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranosyl-(1-->2)]-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranoside] (1) by spectroscopic analysis and the result of acidic hydrolysis. The new saponin (1) as well as known hexasaccharides (3 and 5) isolated here showed cytotoxicity against HeLa cells, and 1 exhibited a cell cycle inhibitory effect at the G2/M stage at the concentration of 7.5 and 10 microg/mL.

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Year:  2004        PMID： 15210151     DOI： 10.1016/j.bmc.2004.05.004

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

1.  Selective Chlorophyll Removal Method to "Degreen" Botanical Extracts.

Authors:  Seon Beom Kim; Jonathan Bisson; J Brent Friesen; Guido F Pauli; Charlotte Simmler
Journal:  J Nat Prod       Date:  2020-05-19       Impact factor: 4.050

2.  Saponins as cytotoxic agents: a review.

Authors:  Irma Podolak; Agnieszka Galanty; Danuta Sobolewska
Journal:  Phytochem Rev       Date:  2010-06-25       Impact factor: 5.374

3.  Fast Centrifugal Partition Chromatography Fractionation of Concentrated Agave (Agave salmiana) Sap to Obtain Saponins with Apoptotic Effect on Colon Cancer Cells.

Authors:  Liliana Santos-Zea; Oscar R Fajardo-Ramírez; Irasema Romo-López; Janet A Gutiérrez-Uribe
Journal:  Plant Foods Hum Nutr       Date:  2016-03       Impact factor: 3.921

4.  Cytotoxic activity of standardized extracts, a fraction, and individual secondary metabolites from fenugreek seeds against SKOV-3, HeLa and MOLT-4 cell lines.

Authors:  Justyna Stefanowicz-Hajduk; Barbara Król-Kogus; Barbara Sparzak-Stefanowska; Katarzyna Kimel; J Renata Ochocka; Mirosława Krauze-Baranowska
Journal:  Pharm Biol       Date:  2021-12       Impact factor: 3.503

5.  Immunomodulatory Effect of Agave tequilana Evaluated on an Autoimmunity Like-SLE Model Induced in Balb/c Mice with Pristane.

Authors:  Zúlima Jannette Gutiérrez Nava; Antonio Ruperto Jiménez-Aparicio; Maribel Lucila Herrera-Ruiz; Enrique Jiménez-Ferrer
Journal:  Molecules       Date:  2017-05-25       Impact factor: 4.411

Review 6.  Potential Use of Agave Genus in Neuroinflammation Management.

Authors:  Maribel Herrera-Ruiz; Enrique Jiménez-Ferrer; Manasés González-Cortazar; Alejandro Zamilpa; Alexandre Cardoso-Taketa; Martha Lucía Arenas-Ocampo; Antonio Ruperto Jiménez-Aparicio; Nayeli Monterrosas-Brisson
Journal:  Plants (Basel)       Date:  2022-08-25

7.  Hydrolysis of Agave fourcroydes Lemaire (henequen) leaf juice and fermentation with Kluyveromyces marxianus for ethanol production.

Authors:  Pablo A Villegas-Silva; Tanit Toledano-Thompson; Blondy B Canto-Canché; Alfonso Larqué-Saavedra; Luis F Barahona-Pérez
Journal:  BMC Biotechnol       Date:  2014-02-14       Impact factor: 2.563

Review 8.  Structure, Bioactivity and Analytical Methods for the Determination of Yucca Saponins.

Authors:  Gabriel G Jiménez; Alexandra G Durán; Francisco A Macías; Ana M Simonet
Journal:  Molecules       Date:  2021-08-30       Impact factor: 4.411
  8 in total

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