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Literature DB >> 15210106

Siah proteins, HIF prolyl hydroxylases, and the physiological response to hypoxia.

Abstract

New evidence suggests that at least two members of the family of hypoxia-inducible factor (HIF) prolyl hydroxylases that regulate HIF stability in response to oxygen (O2) availability are also targeted for proteosome-dependent degradation by the E3 ubiquitin ligases Siah1a and Siah2. This preview examines cellular responses to O2 deprivation (hypoxia) and the complexity of the regulation of the HIF O2 sensing pathway in mammals.

Entities: Chemical Disease Gene

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Year: 2004 PMID： 15210106 DOI： 10.1016/j.cell.2004.06.010

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

7 in total

Review 1. Protons make tumor cells move like clockwork.

Authors: Christian Stock; Albrecht Schwab
Journal: Pflugers Arch Date: 2009-05-13 Impact factor: 3.657

Review 2. Hypoxia-inducible factors and the response to hypoxic stress.

Authors: Amar J Majmundar; Waihay J Wong; M Celeste Simon
Journal: Mol Cell Date: 2010-10-22 Impact factor: 17.970

3. The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression.

Authors: Peter Chan; Andreas Möller; Mira C P Liu; Jaclyn E Sceneay; Christina S F Wong; Nic Waddell; Katie T Huang; Alexander Dobrovic; Ewan K A Millar; Sandra A O'Toole; Catriona M McNeil; Robert L Sutherland; David D Bowtell; Stephen B Fox
Journal: Breast Cancer Res Date: 2011-02-09 Impact factor: 6.466

Review 7. Ubiquitin Ligases Involved in the Regulation of Wnt, TGF-β, and Notch Signaling Pathways and Their Roles in Mouse Development and Homeostasis.

Authors: Nikol Baloghova; Tomas Lidak; Lukas Cermak
Journal: Genes (Basel) Date: 2019-10-16 Impact factor: 4.096

7 in total

Siah proteins, HIF prolyl hydroxylases, and the physiological response to hypoxia.

Review 1. Protons make tumor cells move like clockwork.

Review 2. Hypoxia-inducible factors and the response to hypoxic stress.

3. The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression.

4. Intrabody Targeting HIF-1α Mediates Transcriptional Downregulation of Target Genes Related to Solid Tumors.

5. Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review.

6. SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status.

Review 7. Ubiquitin Ligases Involved in the Regulation of Wnt, TGF-β, and Notch Signaling Pathways and Their Roles in Mouse Development and Homeostasis.