| Literature DB >> 15209561 |
Anna M Vogt1, Gerhard Winter, Mats Wahlgren, Dorothe Spillmann.
Abstract
HS (heparan sulphate) has hitherto not been found on human red blood cells (RBCs, erythrocytes). However, malarial-parasite (Plasmodium falciparum)-infected RBCs adhere to uninfected RBCs via HS-like receptors. In the present paper we demonstrate that human RBCs carry epitopes for an anti-HS antibody. Glycans isolated from RBC membranes reacted to HS-specific degradations and adhered to an HS-binding malaria antigen. Additionally, an HS core protein was identified. This suggests that HS is present on human RBCs.Entities:
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Year: 2004 PMID: 15209561 PMCID: PMC1133867 DOI: 10.1042/BJ20040762
Source DB: PubMed Journal: Biochem J ISSN: 0264-6021 Impact factor: 3.857