Literature DB >> 15209374

PI3-kinase and TOR: PIKTORing cell growth.

Celeste J Richardson1, Stefanie S Schalm, John Blenis.   

Abstract

Regulation of growth and proliferation in higher eukaryotic cells results from an integration of nutritional, energy, and mitogenic signals. Biochemical processes underlying cell growth and proliferation are governed by the phosphatidylinositol 3-kinase (PI3K) and target of rapamycin (TOR) signaling pathways. The importance of the interplay between these two pathways is underscored by the discovery that the TOR inhibitor rapamycin is effective against tumors caused by misregulation of the PI3K pathway. We review here recent data concerning the convergence of the PI3K and TOR pathways, the role of these pathways in cell growth and proliferation, and the regulation of growth by downstream TOR targets.

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Year:  2004        PMID： 15209374     DOI： 10.1016/j.semcdb.2003.12.023

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN： 1084-9521            Impact factor:   7.727


  39 in total

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Authors:  Richard Sever; Joan S Brugge
Journal:  Cold Spring Harb Perspect Med       Date:  2015-04-01       Impact factor: 6.915

2.  Kinetic mechanism of fully activated S6K1 protein kinase.

Authors:  Malik M Keshwani; Thomas K Harris
Journal:  J Biol Chem       Date:  2008-03-06       Impact factor: 5.157

3.  Baculovirus-mediated expression, purification, and characterization of a fully activated catalytic kinase domain construct of the 70 kDa 40S ribosomal protein S6 kinase-1 alphaII isoform (S6K1alphaII).

Authors:  Malik M Keshwani; Duncan B Ross; Timothy J Ragan; Thomas K Harris
Journal:  Protein Expr Purif       Date:  2007-11-19       Impact factor: 1.650

4.  S6 kinase 2 potentiates interleukin-3-driven cell proliferation.

Authors:  Rebecca Cruz; Lee Hedden; Derek Boyer; Michael G Kharas; David A Fruman; Kay K Lee-Fruman
Journal:  J Leukoc Biol       Date:  2005-10-04       Impact factor: 4.962

5.  Effects of PI3K inhibitor NVP-BKM120 on acquired resistance to gefitinib of human lung adenocarcinoma H1975 cells.

Authors:  Yi-Chen Liang; Hong-Ge Wu; Hong-Jian Xue; Qing Liu; Liang-Liang Shi; Tao Liu; Gang Wu
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2013-12-13

6.  Expression, purification, and characterization of a structurally disordered and functional C-terminal autoinhibitory domain (AID) of the 70 kDa 40S ribosomal protein S6 kinase-1 (S6K1).

Authors:  Timothy J Ragan; Duncan B Ross; Malik M Keshwani; Thomas K Harris
Journal:  Protein Expr Purif       Date:  2007-10-01       Impact factor: 1.650

7.  Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1.

Authors:  Nora K McGhee; Leonard S Jefferson; Scot R Kimball
Journal:  J Nutr       Date:  2009-03-18       Impact factor: 4.798

8.  Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4.

Authors:  Teddy T C Yang; Raymond Y L Yu; Anissa Agadir; Guo-Jian Gao; Roberto Campos-Gonzalez; Cathy Tournier; Chi-Wing Chow
Journal:  Mol Cell Biol       Date:  2008-03-17       Impact factor: 4.272

9.  The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse.

Authors:  Alfredo Csibi; Karen Cornille; Marie-Pierre Leibovitch; Anne Poupon; Lionel A Tintignac; Anthony M J Sanchez; Serge A Leibovitch
Journal:  PLoS One       Date:  2010-02-01       Impact factor: 3.240

10.  Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling.

Authors:  Lutz Kockel; Kimberly S Kerr; Michael Melnick; Katja Brückner; Matthias Hebrok; Norbert Perrimon
Journal:  PLoS Genet       Date:  2010-06-17       Impact factor: 5.917
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