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Literature DB >> 15208630

Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors.

Laurent Groc¹, Martin Heine, Laurent Cognet, Kieran Brickley, F Anne Stephenson, Brahim Lounis, Daniel Choquet.

Abstract

The basis for differences in activity-dependent trafficking of AMPA receptors (AMPARs) and NMDA receptors (NMDARs) remains unclear. Using single-molecule tracking, we found different lateral mobilities for AMPARs and NMDARs: changes in neuronal activity modified AMPAR but not NMDAR mobility, whereas protein kinase C activation modified both. Differences in mobility were mainly detected for extrasynaptic AMPARs, suggesting that receptor diffusion between synaptic and extrasynaptic domains is involved in plasticity processes.

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Year: 2004 PMID： 15208630 DOI： 10.1038/nn1270

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

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Cited

150 in total

1. Analysis of microscopic parameters of single-particle trajectories in neurons.

Authors: V M Burlakov; R Taylor; J Koerner; N Emptage
Journal: Biophys J Date: 2010-09-08 Impact factor: 4.033

2. NMDA receptors regulate GABAA receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the γ2 subunit.

Authors: James Muir; I Lorena Arancibia-Carcamo; Andrew F MacAskill; Katharine R Smith; Lewis D Griffin; Josef T Kittler
Journal: Proc Natl Acad Sci U S A Date: 2010-09-07 Impact factor: 11.205

Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors.

1. Analysis of microscopic parameters of single-particle trajectories in neurons.

2. NMDA receptors regulate GABAA receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the γ2 subunit.

3. Dynamic superresolution imaging of endogenous proteins on living cells at ultra-high density.

4. Perisynaptic GluR2-lacking AMPA receptors control the reversibility of synaptic and spines modifications.

5. From analog to digital: exploring cell dynamics with single quantum dots.

6. Targeting quantum dots to surface proteins in living cells with biotin ligase.

Review 7. Organelles and trafficking machinery for postsynaptic plasticity.

8. Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane.

Review 9. Running to stand still: ionotropic receptor dynamics at central and peripheral synapses.

10. Activity-dependent synaptic plasticity in retinal ganglion cells.