Literature DB >> 15208489

Quantification in positron emission tomography for research in pharmacology and drug development.

V J Cunningham1, R N Gunn, J C Matthews.   

Abstract

Positron emission tomography (PET) is a quantitative in vivo tracer technique, enabling images of the distribution of biochemical, physiological and pharmacological functions in living tissue, at a resolution of a few millimetres. Applications include the imaging of blood flow rate, metabolic rate and neuroreceptor distribution and function. These applications are playing an increasing role in drug development. This brief article seeks to emphasize how these applications of PET need to rest on a solid quantitative foundation.

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Year:  2004        PMID： 15208489     DOI： 10.1097/01.mnm.0000134330.38536.bc

Source DB:  PubMed          Journal:  Nucl Med Commun        ISSN： 0143-3636            Impact factor:   1.690


  7 in total

1.  Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy.

Authors:  Sergio Abanades; Jasper van der Aart; Julien A R Barletta; Carmine Marzano; Graham E Searle; Cristian A Salinas; Javaad J Ahmad; Richard R Reiley; Sabina Pampols-Maso; Stefano Zamuner; Vincent J Cunningham; Eugenii A Rabiner; Marc A Laruelle; Roger N Gunn
Journal:  J Cereb Blood Flow Metab       Date:  2010-10-13       Impact factor: 6.200

2.  D₂-receptor occupancy measurement of JNJ-37822681, a novel fast off-rate D₂-receptor antagonist, in healthy subjects using positron emission tomography: single dose versus steady state and dose selection.

Authors:  Mark E Schmidt; Peter de Boer; Randolph Andrews; Martine Neyens; Stefaan Rossenu; Demiana William Falteos; Erik Mannaert
Journal:  Psychopharmacology (Berl)       Date:  2012-07-07       Impact factor: 4.530

3.  In vivo serotonin-sensitive binding of [11C]CUMI-101: a serotonin 1A receptor agonist positron emission tomography radiotracer.

Authors:  Matthew S Milak; Alin J Severance; Jaya Prabhakaran; J S Dileep Kumar; Vattoly J Majo; R Todd Ogden; J John Mann; Ramin V Parsey
Journal:  J Cereb Blood Flow Metab       Date:  2010-06-23       Impact factor: 6.200

4.  Quantification of [18F]UCB-H Binding in the Rat Brain: From Kinetic Modelling to Standardised Uptake Value.

Authors:  Maria Elisa Serrano; Mohamed Ali Bahri; Guillaume Becker; Alain Seret; Frédéric Mievis; Fabrice Giacomelli; Christian Lemaire; Eric Salmon; André Luxen; Alain Plenevaux
Journal:  Mol Imaging Biol       Date:  2019-10       Impact factor: 3.488

5.  Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PET.

Authors:  Dean F Wong; James R Brasić; Harvey S Singer; David J Schretlen; Hiroto Kuwabara; Yun Zhou; Ayon Nandi; Marika A Maris; Mohab Alexander; Weiguo Ye; Olivier Rousset; Anil Kumar; Zsolt Szabo; Albert Gjedde; Anthony A Grace
Journal:  Neuropsychopharmacology       Date:  2007-11-07       Impact factor: 7.853

6.  Nonparametric Residue Analysis of Dynamic PET Data With Application to Cerebral FDG Studies in Normals.

Authors:  Finbarr O'Sullivan; Mark Muzi; Alexander M Spence; David M Mankoff; Janet N O'Sullivan; Niall Fitzgerald; George C Newman; Kenneth A Krohn
Journal:  J Am Stat Assoc       Date:  2009-06-01       Impact factor: 5.033

7.  In Vivo Imaging in Pharmaceutical Development and Its Impact on the 3Rs.

Authors:  Barry R Campbell; Dinko Gonzalez Trotter; Catherine D G Hines; Wenping Li; Manishkumar Patel; Weisheng Zhang; Jeffrey L Evelhoch
Journal:  ILAR J       Date:  2016-12
  7 in total

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