Literature DB >> 15207822

Cytotoxic activity of the lymphocyte toxin granzyme B.

Michelle E Wowk1, Joseph A Trapani.   

Abstract

Cytotoxic lymphocytes protect their host from viral infection and cellular transformation by delivering a range of toxins stored within intracellular granules. One of the most potent of these toxins is the serine protease granzyme B. This review will discuss mechanisms used by granzyme B to enter target cells and the ways in which it synergizes with other granule toxins to cause cell death.

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Year:  2004        PMID： 15207822     DOI： 10.1016/j.micinf.2004.03.008

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  17 in total

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4.  Targeted apoptosis activation with GrB/scFvMEL modulates melanoma growth, metastatic spread, chemosensitivity, and radiosensitivity.

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Authors:  Matthew S Mangan; Carolina R Melo-Silva; Jennii Luu; Catherina H Bird; Aulikki Koskinen; Alexandra Rizzitelli; Monica Prakash; Katrina L Scarff; Arno Müllbacher; Matthias Regner; Phillip I Bird
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Journal:  PLoS One       Date:  2012-07-19       Impact factor: 3.240

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