| Literature DB >> 15207821 |
Shohei Hori1, Shimon Sakaguchi.
Abstract
Regulatory T cells are capable of suppressing deleterious immune responses against self- or non-self-antigens. Their essential role in tolerance and immune regulation has been illustrated by recent findings that mutations in the Foxp3 gene leads to the defective development of regulatory T cells and the emergence of a fatal autoimmune, inflammatory and allergic disease. This review discusses the critical role for this transcription factor in the development and function of regulatory T cells.Entities:
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Year: 2004 PMID： 15207821 DOI： 10.1016/j.micinf.2004.02.020
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700