Literature DB >> 15207104

[Cost relation between severity of Alzheimer's disease and cognitive and functional impairment].

Secundino López-Pousa1, Josep Garre-Olmo, Antoni Turon-Estrada, Francisco Hernández, Inmaculada Expósito, Manoli Lozano-Gallego, Marta Hernández-Ferrándiz, Esther Gelada-Batlle, Imma Pericot-Nierga, Joan Vilalta-Franch.   

Abstract

BACKGROUND AND
OBJECTIVE: This study aims to identify the relationship between costs of medical and social attention in patients with dementia of Alzheimer disease (AD) type and clinical and sociodemographic data of patients and their caregivers. PATIENTS AND
METHOD: It was an analytic observational study in a cohort of patients diagnosed with Alzheimer's disease who received ambulatory attention. Information about the use of health-related resources was collected and costs were estimated from a societal perspective. Indirect costs were calculated using a replacement cost approach. Patients and caregivers were examined with the Mini-Mental State Examination (MMSE), the Rapid Disability Rating Scale (RDRS-2), the Neuropsychiatric Inventory (NPI), the Burden Interview (BI) and the Resource Utilization in Dementia (RUD). Patients were grouped taking into account the score obtained in the MMSE.
RESULTS: A cohort of 417 patients, mean age (SD) 75.2 (6.6) years, 71% females, was studied. Disease severity levels were distributed as follows: MMSE, 26% for MMSE > 19, 66% for MMSE = 19-11, and 8% for MMSE < 11. 69% of caregivers were women, with a mean age of 57.1 (15.8) years. The cost per patient and per month was estimated to be 419.3 Euro for MMSE > 19, 641.9 Euro for MMSE = 19-11, and 1150.6 Euro for MMSE < 11.
CONCLUSIONS: The societal cost of AD increases dramatically with increasing disease severity. Caregiver burden and sex as well as the marital status of patients are associated with the cost of the disease.

Entities:  

Mesh:

Year:  2004        PMID: 15207104     DOI: 10.1016/s0025-7753(04)74381-x

Source DB:  PubMed          Journal:  Med Clin (Barc)        ISSN: 0025-7753            Impact factor:   1.725


  7 in total

Review 1.  Alzheimer's disease: the strength of association of costs with different measures of disease severity.

Authors:  J Mauskopf; J Racketa; E Sherrill
Journal:  J Nutr Health Aging       Date:  2010-10       Impact factor: 4.075

2.  [When should specific pharmacological treatment be stopped in Alzheimer's?].

Authors:  Gabriel Coll-de-Tuero; Secundino López-Pousa; Joan Vilalta-Franch
Journal:  Aten Primaria       Date:  2011-10-05       Impact factor: 1.137

3.  Costs of dementia in the Czech Republic.

Authors:  Iva Holmerová; Jakub Hort; Robert Rusina; Anders Wimo; Michal Šteffl
Journal:  Eur J Health Econ       Date:  2016-10-26

4.  Dementia Still Diagnosed Too Late - Data from the Czech Republic.

Authors:  Jan Luzny; Iva Holmerova; Petr Wija; Igor Ondrejka
Journal:  Iran J Public Health       Date:  2014-10       Impact factor: 1.429

Review 5.  Cost of disorders of the brain in Spain.

Authors:  Oleguer Parés-Badell; Gabriela Barbaglia; Petra Jerinic; Anders Gustavsson; Luis Salvador-Carulla; Jordi Alonso
Journal:  PLoS One       Date:  2014-08-18       Impact factor: 3.240

6.  Detection, diagnosis, and treatment of Alzheimer's disease dementia stratified by severity as reported by caregivers in Japan.

Authors:  William Montgomery; Amir Goren; Kristin Kahle-Wrobleski; Tomomi Nakamura; Kaname Ueda
Journal:  Neuropsychiatr Dis Treat       Date:  2018-07-16       Impact factor: 2.570

7.  Cost-of-illness study in a retrospective cohort of patients with dementia in Lima, Peru.

Authors:  Nilton Custodio; David Lira; Eder Herrera-Perez; Liza Nuñez Del Prado; José Parodi; Erik Guevara-Silva; Sheila Castro-Suarez; Rosa Montesinos
Journal:  Dement Neuropsychol       Date:  2015 Jan-Mar
  7 in total

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