AIMS: Amiodarone is widely used in ventricular tachyarrhythmias and atrial fibrillation, known to prolong QT-intervals. Concurrent administration of drugs prolonging QT- time can induce life-threatening ventricular tachyarrhythmia. METHODS:QT-interval changes following use of Iohexol contrast-medium for coronarangiography were observed comparing 21 patients taking long-term amiodarone therapy with 21 controls not takingamiodarone or QT-prolonging drugs retrospectively. RESULTS: Concurrent use of Iohexol and amiodarone was associated with significant prolongation of QTc-interval (433, 95%CI: 419-448 ms vs. 480, 95%CI: 422-483 ms, P < 0.001) the day after coronarangiograpgy. 6/21 patients showed severe prolonged QTc-interval of >500 ms. CONCLUSION: Caution is advised until more is known about pro-arrhythmic effects of Iohexol.
RCT Entities:
AIMS: Amiodarone is widely used in ventricular tachyarrhythmias and atrial fibrillation, known to prolong QT-intervals. Concurrent administration of drugs prolonging QT- time can induce life-threatening ventricular tachyarrhythmia. METHODS: QT-interval changes following use of Iohexol contrast-medium for coronarangiography were observed comparing 21 patients taking long-term amiodarone therapy with 21 controls not taking amiodarone or QT-prolonging drugs retrospectively. RESULTS: Concurrent use of Iohexol and amiodarone was associated with significant prolongation of QTc-interval (433, 95%CI: 419-448 ms vs. 480, 95%CI: 422-483 ms, P < 0.001) the day after coronarangiograpgy. 6/21 patients showed severe prolonged QTc-interval of >500 ms. CONCLUSION: Caution is advised until more is known about pro-arrhythmic effects of Iohexol.
Authors: F Morady; M J Sauve; P Malone; E N Shen; A B Schwartz; A Bhandari; E Keung; R J Sung; M M Scheinman Journal: Am J Cardiol Date: 1983-11-01 Impact factor: 2.778
Authors: K Nademanee; B N Singh; J Hendrickson; V Intarachot; B Lopez; G Feld; D S Cannom; J L Weiss Journal: Ann Intern Med Date: 1983-05 Impact factor: 25.391