| Literature DB >> 15204925 |
Giuseppe Barbanti-Brodano1, Fernanda Martini, Alfredo Corallini, Lorena Lazzarin, Cecilia Trabanelli, Beatrice Vignocchi, Nilla Calza, Laura Iaccheri, Cristina Morelli, Mauro Tognon.
Abstract
In this study, 82 DNA samples of simian virus 40 (SV40)-positive human tumors and normal tissues were transfected into SV40-permissive monkey cells. SV40 wild-type strain 776 was reactivated from two DNA samples, derived from peripheral blood mononuclear cells (PBMCs) of a blood donor and from a vulvar tissue. SV40 reactivation was confirmed by obtaining rescue of SV40 from the DNA of the vulvar tissue in a second transfection experiment. This investigation indicates that infectious SV40 is present in normal human tissues and suggests that (i) PBMCs are probably vectors of SV40 to different tissues of the host and (ii) blood and sexual transmission may be routes of SV40 infection in humans, leading to (iii) virus spread in the human population.Entities:
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Year: 2004 PMID: 15204925 DOI: 10.1080/13550280490441112
Source DB: PubMed Journal: J Neurovirol ISSN: 1355-0284 Impact factor: 2.643