M E C Robbins1, W Zhao. 1. Departments of Radiation Oncology and Neurosurgery, Brain Tumor Center of Excellence, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. mrobbins@wfubmc.edu
Abstract
PURPOSE: It is proposed that the development and progression of radiation-induced late effects are driven, in part, by chronic oxidative stress. This mini-review presents data to support this hypothesis and provides the foundation for antioxidant-based interventional approaches directed at modulating late normal tissue injury. CONCLUSIONS: Although a causal link between chronic oxidative stress and radiation-induced late normal tissue injury remains to be established, a growing body of evidence appears to support the hypothesis that chronic oxidative stress might serve to drive the progression of radiation-induced late effects. The similarity between chronic tissue injury, chronic inflammation and fibrosis observed in a variety of disease states, including radiation late effects, is provocative and offers the opportunity to apply antioxidant-based therapies to mitigate and/or treat late radiation-induced normal tissue injury.
PURPOSE: It is proposed that the development and progression of radiation-induced late effects are driven, in part, by chronic oxidative stress. This mini-review presents data to support this hypothesis and provides the foundation for antioxidant-based interventional approaches directed at modulating late normal tissue injury. CONCLUSIONS: Although a causal link between chronic oxidative stress and radiation-induced late normal tissue injury remains to be established, a growing body of evidence appears to support the hypothesis that chronic oxidative stress might serve to drive the progression of radiation-induced late effects. The similarity between chronic tissue injury, chronic inflammation and fibrosis observed in a variety of disease states, including radiation late effects, is provocative and offers the opportunity to apply antioxidant-based therapies to mitigate and/or treat late radiation-induced normal tissue injury.
Authors: Christina K Cramer; Tiffany L Cummings; Rachel N Andrews; Roy Strowd; Stephen R Rapp; Edward G Shaw; Michael D Chan; Glenn J Lesser Journal: Curr Treat Options Oncol Date: 2019-04-08