PRIMARY OBJECTIVE: To evaluate the effects of administering Donepezil during inpatient rehabilitation for individuals with TBI. RESEARCH DESIGN: Retrospective, age and injury severity matched, mixed between-within subjects analysis. METHODS AND PROCEDURES: Thirty-six patients with moderate-to-severe TBI admitted to acute rehabilitation within 90 days of injury. Main outcome measures included FIM cognitive total scores and rehabilitation lengths of stay. INTERVENTION: Initiation of Donepezil administration beginning at 5 mg daily. Dose titration and continuation based on perceived clinical response. MAIN OUTCOMES AND RESULTS: No differences in cognitive improvement were observed between the Donepezil treatment group and the matched control group. Sub-set analyses suggested that administration of Donepezil early in the rehabilitation stay was significantly related to higher rates of cognitive improvement. CONCLUSIONS: Preliminary evidence suggests that Donepezil administration early in the rehabilitation stay may have advantageous treatment effects. A prospective, randomized, placebo-controlled clinical trial with standard timing, dosage and treatment duration is recommended to further evaluate treatment efficacy.
RCT Entities:
PRIMARY OBJECTIVE: To evaluate the effects of administering Donepezil during inpatient rehabilitation for individuals with TBI. RESEARCH DESIGN: Retrospective, age and injury severity matched, mixed between-within subjects analysis. METHODS AND PROCEDURES: Thirty-six patients with moderate-to-severe TBI admitted to acute rehabilitation within 90 days of injury. Main outcome measures included FIM cognitive total scores and rehabilitation lengths of stay. INTERVENTION: Initiation of Donepezil administration beginning at 5 mg daily. Dose titration and continuation based on perceived clinical response. MAIN OUTCOMES AND RESULTS: No differences in cognitive improvement were observed between the Donepezil treatment group and the matched control group. Sub-set analyses suggested that administration of Donepezil early in the rehabilitation stay was significantly related to higher rates of cognitive improvement. CONCLUSIONS: Preliminary evidence suggests that Donepezil administration early in the rehabilitation stay may have advantageous treatment effects. A prospective, randomized, placebo-controlled clinical trial with standard timing, dosage and treatment duration is recommended to further evaluate treatment efficacy.
Authors: Elliott J Mufson; Sylvia E Perez; Muhammad Nadeem; Laura Mahady; Nicholas M Kanaan; Eric E Abrahamson; Milos D Ikonomovic; Fiona Crawford; Victor Alvarez; Thor Stein; Ann C McKee Journal: Brain Inj Date: 2016 Impact factor: 2.311
Authors: Kaitlyn E Shaw; Corina O Bondi; Samuel H Light; Lire A Massimino; Rose L McAloon; Christina M Monaco; Anthony E Kline Journal: J Neurotrauma Date: 2013-03-26 Impact factor: 5.269
Authors: Ramon Diaz-Arrastia; Patrick M Kochanek; Peter Bergold; Kimbra Kenney; Christine E Marx; Col Jamie B Grimes; L T C Yince Loh; L T C Gina E Adam; Devon Oskvig; Kenneth C Curley; Wanda Salzer Journal: J Neurotrauma Date: 2014-01-15 Impact factor: 5.269
Authors: Elliott J Mufson; Bin He; Stephen D Ginsberg; Benjamin A Carper; Gayle S Bieler; Fiona Crawford; Victor E Alvarez; Bertrand R Huber; Thor D Stein; Ann C McKee; Sylvia E Perez Journal: J Neurotrauma Date: 2018-04-05 Impact factor: 5.269
Authors: David B Arciniegas; C Alan Anderson; Jeannie Topkoff; Thomas W McAllister Journal: Neuropsychiatr Dis Treat Date: 2005-12 Impact factor: 2.570