| Literature DB >> 15203165 |
Li-Qiang Sun1, Jie Chen, Marc Bruce, Jeffrey A Deskus, James R Epperson, Katherine Takaki, Graham Johnson, Lawrence Iben, Cathy D Mahle, Elaine Ryan, Cen Xu.
Abstract
A series of benzoxazole derivatives was synthesized and evaluated as melatoninergic ligands. The binding affinity of these compounds for human MT(1) and MT(2) receptors was determined using 2-[(125)I]-iodomelatonin as the radioligand. From this series of benzoxazole derivatives, compounds 14 and 17 were identified as melatonin receptor agonists.Entities:
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Year: 2004 PMID： 15203165 DOI： 10.1016/j.bmcl.2004.04.082
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823