Literature DB >> 15203144

Design, synthesis and cytotoxic studies on the simplified oxy analog of eleutherobin.

S Chandrasekhar1, V Jagadeshwar, Ch Narsihmulu, M Sarangapani, D R Krishna, J Vidyasagar, Dolly Vijay, G Narahari Sastry.   

Abstract

A straight forward entry into nine membered B ring of eleutherobin as oxy analog and its cyctotoxic properties on HBL cell lines is described. Molecular modeling studies were carried out to ascertain the binding of the model compound to the active site of beta-tubulin.

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Year:  2004        PMID: 15203144     DOI: 10.1016/j.bmcl.2004.05.017

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Phylogeny drives large scale patterns in Australian marine bioactivity and provides a new chemical ecology rationale for future biodiscovery.

Authors:  Elizabeth A Evans-Illidge; Murray Logan; Jason Doyle; Jane Fromont; Christopher N Battershill; Gavin Ericson; Carsten W Wolff; Andrew Muirhead; Phillip Kearns; David Abdo; Stuart Kininmonth; Lyndon Llewellyn
Journal:  PLoS One       Date:  2013-09-05       Impact factor: 3.240

  1 in total

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