| Literature DB >> 15203136 |
Małgorzata Dukat1, Mohamed Taroua, Abdelaziz Dahdouh, Umamaheswar Siripurapu, M Imad Damaj, Billy R Martin, Richard A Glennon.
Abstract
Several amine-substituted 8-amino-5,6,7,8-tetrahydroisoquinolines were examined as conformationally-constrained analogs of the nicotinic cholinergic (nACh) 3-(aminomethyl)pyridines. Although these ligands failed to bind at nACh receptors, the N-ethyl-N-methyl analog 3d was found to be at least equipotent with nicotine in rodent tests of antinociception. The mechanism of action of 3d is currently unknown.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15203136 DOI： 10.1016/j.bmcl.2004.05.020
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823