PURPOSE: To report a case of arterial calcification in a person who has had long-term treatment with warfarin. Although the anticoagulant has been shown to induce arterial calcification in laboratory animals, there have been no previous reports implicating warfarin as a clinical factor. CLINICAL FEATURES: On routine annual examination, the coronary arteries of a healthy man with no symptoms who has had long-term warfarin treatment were found to be highly calcified. CONCLUSION: It would be prudent to further evaluate experimentally the relationship of warfarin and arterial calcification. We suggest that physicians prescribing long-term warfarin treatment consider arterial calcification as one of its potential consequences.
PURPOSE: To report a case of arterial calcification in a person who has had long-term treatment with warfarin. Although the anticoagulant has been shown to induce arterial calcification in laboratory animals, there have been no previous reports implicating warfarin as a clinical factor. CLINICAL FEATURES: On routine annual examination, the coronary arteries of a healthy man with no symptoms who has had long-term warfarin treatment were found to be highly calcified. CONCLUSION: It would be prudent to further evaluate experimentally the relationship of warfarin and arterial calcification. We suggest that physicians prescribing long-term warfarin treatment consider arterial calcification as one of its potential consequences.
Authors: Veena Naik; Elizabeth M Leaf; Jie Hong Hu; Hsueh-Ying Yang; Ngoc B Nguyen; Cecilia M Giachelli; Mei Y Speer Journal: Cardiovasc Res Date: 2012-03-21 Impact factor: 10.787
Authors: Mei Y Speer; Hsueh-Ying Yang; Thea Brabb; Elizabeth Leaf; Amy Look; Wei-Ling Lin; Andrew Frutkin; David Dichek; Cecilia M Giachelli Journal: Circ Res Date: 2009-02-05 Impact factor: 17.367
Authors: Krista Nuotio; Suvi M Koskinen; Laura Mäkitie; Jarno Tuimala; Petra Ijäs; Hanna M Heikkilä; Jani Saksi; Pirkka Vikatmaa; Pia Sorto; Sonja Kasari; Ilari Paakkari; Heli Silvennoinen; Leena Valanne; Mikko I Mäyränpää; Lauri Soinne; Petri T Kovanen; Perttu J Lindsberg Journal: Front Neurol Date: 2021-07-12 Impact factor: 4.003