Literature DB >> 15202729

ISAtx-247 (Isotechnika/Roche).

Francis J Dumont1.   

Abstract

ISAtx-247 is a ciclosporin A analog under development by Isotechnika and Roche as an immunosuppressant for the potential prevention of organ rejection after transplantation, and for the potential treatment of autoimmune diseases such as rheumatoid arthritis, psoriasis and type 1 diabetes. A phase II renal transplantation study had been completed by June 2003.

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Year:  2004        PMID： 15202729

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN： 1472-4472


  6 in total

1.  [Systemic voclosporin for uveitis treatment].

Authors:  C M E Deuter
Journal:  Ophthalmologe       Date:  2010-07       Impact factor: 1.059

2.  Calcineurin Inhibitor Voclosporin Preserves Corneal Barrier and Conjunctival Goblet Cells in Experimental Dry Eye.

Authors:  Jehan Alam; Rodrigo G de Souza; Zhiyuan Yu; Michael E Stern; Cintia S de Paiva; Stephen C Pflugfelder
Journal:  J Ocul Pharmacol Ther       Date:  2020-07-23       Impact factor: 2.671

3.  Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin).

Authors:  Andreas Kuglstatter; Francis Mueller; Eric Kusznir; Bernard Gsell; Martine Stihle; Ralf Thoma; Joerg Benz; Launa Aspeslet; Derrick Freitag; Michael Hennig
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2011-01-15

4.  Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis.

Authors:  Martin Roesel; Christoph Tappeiner; Arnd Heiligenhaus; Carsten Heinz
Journal:  Clin Ophthalmol       Date:  2011-09-13

5.  A new agent for the treatment of noninfectious uveitis: rationale and design of three LUMINATE (Lux Uveitis Multicenter Investigation of a New Approach to Treatment) trials of steroid-sparing voclosporin.

Authors:  Eddy Anglade; Launa J Aspeslet; Sidney L Weiss
Journal:  Clin Ophthalmol       Date:  2008-12

Review 6.  Pharmacotherapy for uveitis: current management and emerging therapy.

Authors:  Robert J Barry; Quan Dong Nguyen; Richard W Lee; Philip I Murray; Alastair K Denniston
Journal:  Clin Ophthalmol       Date:  2014-09-22
  6 in total

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