Literature DB >> 15200500

Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism.

C L Wellington1.   

Abstract

Alzheimer's Disease (AD) is a devastating disease that affects millions of elderly persons. Despite years of intense investigations, genetic risk factors that affect the majority of AD cases have yet to be determined. Recent studies suggest that cholesterol metabolism has integral part in AD pathogenesis, suggesting that genes that regulate lipid metabolism may also play roles in AD. This review will first describe emerging evidence that links cholesterol to the mechanisms thought to underlie AD. Based on this rationale, candidate genes located in regions implicated in AD that have roles in lipid metabolism will then be discussed.

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Year:  2004        PMID： 15200500     DOI： 10.1111/j.0009-9163.2004.00280.x

Source DB:  PubMed          Journal:  Clin Genet        ISSN： 0009-9163            Impact factor:   4.438


  22 in total

1.  Early Presymptomatic Changes in the Proteome of Mitochondria-Associated Membrane in the APP/PS1 Mouse Model of Alzheimer's Disease.

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Journal:  Mol Neurobiol       Date:  2018-02-22       Impact factor: 5.590

Review 2.  Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD).

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Journal:  Prog Retin Eye Res       Date:  2010-03-03       Impact factor: 21.198

3.  Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration.

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Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-03       Impact factor: 11.205

4.  Mutations of a Drosophila NPC1 gene confer sterol and ecdysone metabolic defects.

Authors:  Megan L Fluegel; Tracey J Parker; Leo J Pallanck
Journal:  Genetics       Date:  2005-08-03       Impact factor: 4.562

5.  Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys.

Authors:  Chongren Tang; Jenny E Kanter; Karin E Bornfeldt; Renee C Leboeuf; John F Oram
Journal:  J Lipid Res       Date:  2009-11-23       Impact factor: 5.922

6.  Cardiovascular dementia - a different perspective.

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Journal:  Open Biochem J       Date:  2010-03-26

7.  Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits.

Authors:  Celine Ullrich; Michael Pirchl; Christian Humpel
Journal:  Mol Cell Neurosci       Date:  2010-08-06       Impact factor: 4.314

Review 8.  The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications.

Authors:  Qingguang Jiang; Michael Heneka; Gary E Landreth
Journal:  CNS Drugs       Date:  2008       Impact factor: 5.749

Review 9.  Lipid rafts, cholesterol, and the brain.

Authors:  Zeljka Korade; Anne K Kenworthy
Journal:  Neuropharmacology       Date:  2008-03-14       Impact factor: 5.250

10.  Neurobiology of Alzheimer's disease.

Authors:  E Mohandas; V Rajmohan; B Raghunath
Journal:  Indian J Psychiatry       Date:  2009-01       Impact factor: 1.759
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