Literature DB >> 15200334

A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates.

Weidong Wu1, Caren L Freel Meyers, Richard F Borch.   

Abstract

[reaction: see text] A novel method for the preparation of nucleoside triphosphates has been developed. The strategy employs a highly reactive pyrrolidinium phosphoramidate zwitterion intermediate that undergoes efficient coupling with tris(tetra-n-butylammonium) hydrogen pyrophosphate to generate nucleoside triphosphate.

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Year:  2004        PMID： 15200334     DOI： 10.1021/ol049267j

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  9 in total

1.  Synthesis of nucleoside 5'-O-alpha,beta-methylene-beta-triphosphates and evaluation of their potency towards inhibition of HIV-1 reverse transcriptase.

Authors:  Y Ahmadibeni; C Dash; M J Hanley; S F J Le Grice; H K Agarwal; K Parang
Journal:  Org Biomol Chem       Date:  2010-01-13       Impact factor: 3.876

2.  Inhibition of multi-drug resistant HIV-1 reverse transcriptase by nucleoside β-triphosphates.

Authors:  Chandravanu Dash; Yousef Ahmadibeni; Michael J Hanley; Jui Pandhare; Mathias Gotte; Stuart F J Le Grice; Keykavous Parang
Journal:  Bioorg Med Chem Lett       Date:  2011-05-08       Impact factor: 2.823

3.  Protection-free one-pot synthesis of 2'-deoxynucleoside 5'-triphosphates and DNA polymerization.

Authors:  Julianne Caton-Williams; Matthew Smith; Nicolas Carrasco; Zhen Huang
Journal:  Org Lett       Date:  2011-07-26       Impact factor: 6.005

4.  Synthesis of β-triphosphotriester pronucleotides.

Authors:  Yousef Beni; Chandravanu Dash; Keykavous Parang
Journal:  Tetrahedron Lett       Date:  2015-03-16       Impact factor: 2.415

5.  One-pot synthesis of nucleoside 5'-triphosphates from nucleoside 5'-H-phosphonates.

Authors:  Qi Sun; Jocelyn P Edathil; Runzhi Wu; Eric D Smidansky; Craig E Cameron; Blake R Peterson
Journal:  Org Lett       Date:  2008-04-08       Impact factor: 6.005

6.  Use of a novel 5'-regioselective phosphitylating reagent for one-pot synthesis of nucleoside 5'-triphosphates from unprotected nucleosides.

Authors:  Julianne Caton-Williams; Rudiona Hoxhaj; Bilal Fiaz; Zhen Huang
Journal:  Curr Protoc Nucleic Acid Chem       Date:  2013-03

7.  Synthesis and biological activity of a gemcitabine phosphoramidate prodrug.

Authors:  Weidong Wu; Jennifer Sigmond; Godefridus J Peters; Richard F Borch
Journal:  J Med Chem       Date:  2007-06-29       Impact factor: 7.446

8.  The synthesis of 2'-methylseleno adenosine and guanosine 5'-triphosphates.

Authors:  Tobias Santner; Vanessa Siegmund; Andreas Marx; Ronald Micura
Journal:  Bioorg Med Chem       Date:  2012-02-04       Impact factor: 3.641

Review 9.  Nucleoside triphosphates--building blocks for the modification of nucleic acids.

Authors:  Marcel Hollenstein
Journal:  Molecules       Date:  2012-11-15       Impact factor: 4.411
  9 in total

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