Literature DB >> 15200150

The role of the calcium-sensing receptor in epidermal differentiation.

Chia-Ling Tu1, Yuko Oda, Laszlo Komuves, Daniel D Bikle.   

Abstract

Calcium regulates the proliferation and differentiation of keratinocytes both in vivo and in vitro. Elevated extracellular Ca2+ concentration ([Ca2+]o) raises the intracellular free calcium ([Ca2+]i) and activates differentiation-related genes. Cells lacking the calcium-sensing receptor (CaR) fail to respond to [Ca2+]o and to differentiate, indicating a role for CaR in keratinocyte differentiation. These concepts derived from in vitro experiments have been tested and confirmed in two mouse models.

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Year:  2004        PMID： 15200150     DOI： 10.1016/j.ceca.2003.10.019

Source DB:  PubMed          Journal:  Cell Calcium        ISSN： 0143-4160            Impact factor:   6.817


  45 in total

1.  Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.

Authors:  Aya Yamamura; Qiang Guo; Hisao Yamamura; Adriana M Zimnicka; Nicole M Pohl; Kimberly A Smith; Ruby A Fernandez; Amy Zeifman; Ayako Makino; Hui Dong; Jason X-J Yuan
Journal:  Circ Res       Date:  2012-06-22       Impact factor: 17.367

2.  Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1{alpha} (mGluR1{alpha}) that controls receptor activation.

Authors:  Yusheng Jiang; Yun Huang; Hing-Cheung Wong; Yubin Zhou; Xue Wang; Jun Yang; Randy A Hall; Edward M Brown; Jenny J Yang
Journal:  J Biol Chem       Date:  2010-08-12       Impact factor: 5.157

Review 3.  Extracellular calcium as an integrator of tissue function.

Authors:  Gerda E Breitwieser
Journal:  Int J Biochem Cell Biol       Date:  2008-02-02       Impact factor: 5.085

4.  Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor.

Authors:  Yun Huang; Yubin Zhou; Wei Yang; Robert Butters; Hsiau-Wei Lee; Shunyi Li; Adriana Castiblanco; Edward M Brown; Jenny J Yang
Journal:  J Biol Chem       Date:  2007-05-03       Impact factor: 5.157

5.  Specific TRPC6 channel activation, a novel approach to stimulate keratinocyte differentiation.

Authors:  Margarethe Müller; Kirill Essin; Kerstin Hill; Heike Beschmann; Simone Rubant; Christoph M Schempp; Maik Gollasch; W Henning Boehncke; Christian Harteneck; Walter E Müller; Kristina Leuner
Journal:  J Biol Chem       Date:  2008-09-25       Impact factor: 5.157

6.  Calcium sensing receptor activation elevates proinflammatory factor expression in human adipose cells and adipose tissue.

Authors:  Mariana Cifuentes; Cecilia Fuentes; Nicolas Tobar; Ingrid Acevedo; Elisa Villalobos; Eric Hugo; Nira Ben-Jonathan; Marcela Reyes
Journal:  Mol Cell Endocrinol       Date:  2012-03-16       Impact factor: 4.102

Review 7.  Forms and functions of store-operated calcium entry mediators, STIM and Orai.

Authors:  James W Putney
Journal:  Adv Biol Regul       Date:  2017-11-22

8.  SIRT1 promotes differentiation of normal human keratinocytes.

Authors:  Gil Blander; Anupama Bhimavarapu; Thomas Mammone; Daniel Maes; Keith Elliston; Christian Reich; Mary Steidl Matsui; Leonard Guarente; Joseph Jorge Loureiro
Journal:  J Invest Dermatol       Date:  2008-06-19       Impact factor: 8.551

9.  Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome.

Authors:  Helmuth A Sánchez; Gülistan Mese; Miduturu Srinivas; Thomas W White; Vytas K Verselis
Journal:  J Gen Physiol       Date:  2010-07       Impact factor: 4.086

Review 10.  The role of the calcium-sensing receptor in bone biology and pathophysiology.

Authors:  T A Theman; M T Collins
Journal:  Curr Pharm Biotechnol       Date:  2009-04       Impact factor: 2.837
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