| Literature DB >> 15198585 |
Jingjing Li1, Jing Wu, Angela S Fleischhacker, Ronald W Woodard.
Abstract
The Aquifex aeolicus 3-deoxy-d-manno-octulosonate 8-phosphate synthase (KDO8PS), a class II metalloenzyme, is converted into an active nonmetalloenzyme by a single amino acid mutation, namely, C11N. The result may provide insight into the evolutionary link between the two KDO8PS classes as well as the potential role of the metal and/or asparagine in the catalytic mechanism.Entities:
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Year: 2004 PMID： 15198585 DOI： 10.1021/ja0480872
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419