| Literature DB >> 15196924 |
Olga Gutierrez1, Carlos Pipaon, Jose L Fernandez-Luna.
Abstract
Ipaf has been associated with apoptosis, cytokine processing, and nuclear factor-kappaB activation. Here, we describe that Ipaf is highly expressed in myelomonocytic cells and that the mRNA levels of Ipaf progressively increase during differentiation of CD34(+) progenitors to granulocytes and monocytes. Additionally, treatment with tumor necrosis factor-alpha and exposure to UV radiation induced the transcriptional activation of Ipaf in human leukemia HL-60 cells. Thus, Ipaf may contribute to modulate the response of myeloid cells to genotoxic and pro-inflammatory stimuli.Entities:
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Year: 2004 PMID： 15196924 DOI： 10.1016/j.febslet.2004.04.095
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124