Literature DB >> 15196804

Antagonism of nitrous oxide antinociception in mice by antisense oligodeoxynucleotide directed against neuronal nitric oxide synthase enzyme.

Shuang Li1, Andrew J Bieber, Raymond M Quock.   

Abstract

Nitric oxide (NO) has been implicated in the antinociceptive effect of nitrous oxide (N2O) in mice. This study was conducted to determine the sensitivity of N2O-induced antinociception to antagonism by an antisense oligodeoxynucleotide (AS-ODN) against neuronal nitric oxide synthase (nNOS). The AS-ODN significantly antagonized the antinociceptive effect of N2O in the abdominal constriction test, but a mismatch ODN was without effect. This result implicates the specific involvement of nNOS in N2O-induced antinociception. Copyright 2003 Elsevier B.V.

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Year:  2004        PMID： 15196804     DOI： 10.1016/j.bbr.2003.10.019

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN： 0166-4328            Impact factor:   3.332


  5 in total

1.  Involvement of a NO-cyclic GMP-PKG signaling pathway in nitrous oxide-induced antinociception in mice.

Authors:  Yao Zhang; Lindsay P Quock; Eunhee Chung; Yusuke Ohgami; Raymond M Quock
Journal:  Eur J Pharmacol       Date:  2011-01-14       Impact factor: 4.432

2.  Nitrous oxide-induced NO-dependent neuronal release of β-endorphin from the rat arcuate nucleus and periaqueductal gray.

Authors:  Yusuke Ohgami; Eunhee Chung; Raymond M Quock
Journal:  Brain Res       Date:  2010-11-06       Impact factor: 3.252

Review 3.  Advances in understanding the actions of nitrous oxide.

Authors:  Dimitris E Emmanouil; Raymond M Quock
Journal:  Anesth Prog       Date:  2007

4.  Nitrous oxide-antinociception is mediated by opioid receptors and nitric oxide in the periaqueductal gray region of the midbrain.

Authors:  Dimitris E Emmanouil; Andrea S Dickens; Rick W Heckert; Yusuke Ohgami; Eunhee Chung; Shujie Han; Raymond M Quock
Journal:  Eur Neuropsychopharmacol       Date:  2007-08-01       Impact factor: 4.600

5.  Exposure to nitrous oxide stimulates a nitric oxide-dependent neuronal release of beta-endorphin in ventricular-cisternally-perfused rats.

Authors:  Lisa M Zelinski; Yusuke Ohgami; Raymond M Quock
Journal:  Brain Res       Date:  2009-09-09       Impact factor: 3.252
  5 in total

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