| Literature DB >> 15196561 |
Maria K Vartiainen1, Laura M Machesky.
Abstract
Arp2/3 complex nucleates the formation of dendritic actin filament arrays, which are especially prominent at the leading edges of motile cells. Recent genetic and other loss-of-function studies have highlighted the importance of the Arp2/3 complex for normal cell functions, and especially for cell motility. WASP/Scar family proteins regulate the activity of the Arp2/3 complex, and also link it to several signaling pathways. Recent studies suggest that Scar is a more important regulator of Arp2/3 activity in actin-dependent morphological processes than WASP, which may have a more restricted role in specialized cellular events. It has also become clear that precise regulation of both Scar and WASP activity is of the utmost importance for their physiological functions.Entities:
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Year: 2004 PMID： 15196561 DOI： 10.1016/j.ceb.2004.02.004
Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382