Literature DB >> 15196236

The candidate gene approach: have murine models informed the study of human SLE?

D S Cunninghame Graham1, T J Vyse.   

Abstract

Genome wide linkage studies in human SLE have identified seven highly significant loci linked to SLE, and more than 20 other loci showing suggestive linkage to disease. However, pin-pointing the susceptibility alleles in candidate genes within these linkage regions is challenging, due the genetic heterogeneity, racial differences and environmental influences on disease aetiology. Utilization of murine models of spontaneous lupus nephritis provide a complementary approach, which may then identify candidate genes for analysis in human cases. This review highlights the utility of cross-species approach to identify and characterize the effect of given candidate genes in lupus. The examples described in this review demonstrate the importance of bringing together both genetic and functional information in human and mouse studies.

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Year:  2004        PMID： 15196236      PMCID： PMC1809082          DOI： 10.1111/j.1365-2249.2004.02525.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  76 in total

1.  A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease.

Authors:  J Wu; J C Edberg; P B Redecha; V Bansal; P M Guyre; K Coleman; J E Salmon; R P Kimberly
Journal:  J Clin Invest       Date:  1997-09-01       Impact factor: 14.808

Review 2.  Fc receptors.

Authors:  J V Ravetch
Journal:  Curr Opin Immunol       Date:  1997-02       Impact factor: 7.486

3.  Fc gamma RIIa polymorphism in systemic lupus erythematosus (SLE): no association with disease.

Authors:  M Botto; E Theodoridis; E M Thompson; H L Beynon; D Briggs; D A Isenberg; M J Walport; K A Davies
Journal:  Clin Exp Immunol       Date:  1996-05       Impact factor: 4.330

Review 4.  Genetic analysis of autoimmune disease.

Authors:  T J Vyse; J A Todd
Journal:  Cell       Date:  1996-05-03       Impact factor: 41.582

5.  Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice.

Authors:  T J Vyse; S J Rozzo; C G Drake; S Izui; B L Kotzin
Journal:  J Immunol       Date:  1997-06-01       Impact factor: 5.422

6.  Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes.

Authors:  H Nishimura; Y Agata; A Kawasaki; M Sato; S Imamura; N Minato; H Yagita; T Nakano; T Honjo
Journal:  Int Immunol       Date:  1996-05       Impact factor: 4.823

7.  Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.

Authors:  Y Agata; A Kawasaki; H Nishimura; Y Ishida; T Tsubata; H Yagita; T Honjo
Journal:  Int Immunol       Date:  1996-05       Impact factor: 4.823

8.  Backcross analysis of genes linked to autoantibody production in New Zealand White mice.

Authors:  T J Vyse; L Morel; F J Tanner; E K Wakeland; B L Kotzin
Journal:  J Immunol       Date:  1996-09-15       Impact factor: 5.422

9.  Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice.

Authors:  T Takai; M Ono; M Hikida; H Ohmori; J V Ravetch
Journal:  Nature       Date:  1996-01-25       Impact factor: 49.962

10.  Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.

Authors:  J E Salmon; S Millard; L A Schachter; F C Arnett; E M Ginzler; M F Gourley; R Ramsey-Goldman; M G Peterson; R P Kimberly
Journal:  J Clin Invest       Date:  1996-03-01       Impact factor: 14.808
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  6 in total

1.  Familial chilblain lupus, a monogenic form of cutaneous lupus erythematosus, maps to chromosome 3p.

Authors:  Min Ae Lee-Kirsch; Maolian Gong; Herbert Schulz; Franz Rüschendorf; Annette Stein; Christiane Pfeiffer; Annalisa Ballarini; Manfred Gahr; Norbert Hubner; Maja Linné
Journal:  Am J Hum Genet       Date:  2006-08-17       Impact factor: 11.025

2.  The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice.

Authors:  Hideharu Sekine; Ting Ting Hsieh Kinser; Fei Qiao; Efrain Martinez; Emily Paulling; Phillip Ruiz; Gary S Gilkeson; Stephen Tomlinson
Journal:  Arthritis Rheum       Date:  2011-04

3.  Lymphocytes with aberrant expression of Fas or Fas ligand attenuate immune bone marrow failure in a mouse model.

Authors:  Stephanie O Omokaro; Marie J Desierto; Michael A Eckhaus; Felicia M Ellison; Jichun Chen; Neal S Young
Journal:  J Immunol       Date:  2009-03-15       Impact factor: 5.422

Review 4.  The NLR network and the immunological disease continuum of adaptive and innate immune-mediated inflammation against self.

Authors:  Dennis McGonagle; Sinisa Savic; Michael F McDermott
Journal:  Semin Immunopathol       Date:  2007-09-06       Impact factor: 11.759

Review 5.  Sex-specific effects of LiCl treatment on preservation of renal function and extended life-span in murine models of SLE: perspective on insights into the potential basis for survivorship in NZB/W female mice.

Authors:  David A Hart
Journal:  Biol Sex Differ       Date:  2016-06-27       Impact factor: 5.027

Review 6.  Current status of lupus genetics.

Authors:  Andrea L Sestak; Swapan K Nath; Amr H Sawalha; John B Harley
Journal:  Arthritis Res Ther       Date:  2007       Impact factor: 5.156
  6 in total

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