A Markopoulos1, E Albanidou-Farmaki, I Kayavis. 1. Department of Oral Medicine and Pathology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece. anmark@dent.auth.gr
Abstract
OBJECTIVE: The purpose of this study was to determine the clinical and histopathologic presentation of actinic cheilitis. STUDY DESIGN: A retrospective study on 65 patients attending an Oral Medicine clinic in Greece over a 10 year period. For each case the demographic, clinical and histopathologic information were evaluated. RESULTS: The mean age at the time of diagnosis was 53.1 +/- 11.4 years. Thirty-nine patients (60%) used tobacco in any form. An outdoor occupation was indicated for 43 (66.2%) patients. The location of the lesions of actinic cheilitis was in all cases on the lower lip. Actinic cheilitis appeared in three forms; white non-ulcerated lesions (29%), erosions or ulcers of the lip (48%), mixed white and erosive (23%). The histopathologic characteristics included increased thickness of keratin layer, alterations of the thickness of spinous cell layer, epithelial dysplasia, connective tissue changes, perivascular inflammation and basophilic changes of connective tissue. In 11 cases (16.9%) the presence of squamous cell carcinoma was observed. CONCLUSIONS: This case-series highlights varied clinical presentation of actinic cheilitis among whom a high proportion developed squamous cell carcinoma.
OBJECTIVE: The purpose of this study was to determine the clinical and histopathologic presentation of actinic cheilitis. STUDY DESIGN: A retrospective study on 65 patients attending an Oral Medicine clinic in Greece over a 10 year period. For each case the demographic, clinical and histopathologic information were evaluated. RESULTS: The mean age at the time of diagnosis was 53.1 +/- 11.4 years. Thirty-nine patients (60%) used tobacco in any form. An outdoor occupation was indicated for 43 (66.2%) patients. The location of the lesions of actinic cheilitis was in all cases on the lower lip. Actinic cheilitis appeared in three forms; white non-ulcerated lesions (29%), erosions or ulcers of the lip (48%), mixed white and erosive (23%). The histopathologic characteristics included increased thickness of keratin layer, alterations of the thickness of spinous cell layer, epithelial dysplasia, connective tissue changes, perivascular inflammation and basophilic changes of connective tissue. In 11 cases (16.9%) the presence of squamous cell carcinoma was observed. CONCLUSIONS: This case-series highlights varied clinical presentation of actinic cheilitis among whom a high proportion developed squamous cell carcinoma.
Authors: Leni Verônica de Oliveira Silva; José Alcides Almeida de Arruda; Lucas Guimarães Abreu; Raquel Conceição Ferreira; Leorik Pereira da Silva; Cibele Pelissari; Ricardo Natã Fonseca Silva; Kaio Heide Sampaio Nóbrega; Bruno Augusto Benevenuto de Andrade; Mario José Romañach; Michelle Agostini; Cassiano Francisco Weege Nonaka; Pollianna Muniz Alves; Hélder Antônio Rebelo Pontes; Luís Fernando Rivero; Lélia Batista de Souza; Marília Trierveiler; Elismauro Francisco Mendonça; Ana Paula Neutzling Gomes; Manoela Domingues Martins; Emanuel Sávio de Souza Andrade; Marcia Maria Fonseca da Silveira; Ana Paula Veras Sobral; Ricardo Alves Mesquita Journal: Head Neck Pathol Date: 2020-02-19
Authors: Maria da Conceição Andrade de Freitas; Luciana Maria Pedreira Ramalho; Flávia Caló Aquino Xavier; André Luis Gomes Moreira; Sílvia Regina Almeida Reis Journal: J Appl Oral Sci Date: 2008 Nov-Dec Impact factor: 2.698