| Literature DB >> 15196006 |
Frank Bühling1, Ulrich Peitz, Sabine Krüger, Dörthe Küster, Michael Vieth, Ingrid Gebert, Albert Roessner, Ekkehard Weber, Peter Malfertheiner, Thomas Wex.
Abstract
The expression of cathepsins K, L, B, X and W was studied by quantitative RT-PCR in normal and inflamed gastric mucosa (antrum, corpus, cardia). Cathepsins B, L, K and X were expressed ubiquitously. In contrast, cathepsin W was expressed at very low levels. Infection by Helicobacter pylori caused a significant induction of cathepsin X (p<0.008), whereas the other cathepsins were not or only locally affected by H. pylori infection or reflux disease. Immunohistochemistry revealed specific expression of cathepsin X (macrophages), cathepsin K (parietal cells) and cathepsin W (lymphocytes), whereas cathepsins B and L were predominantly expressed in epithelial cells.Entities:
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Year: 2004 PMID： 15196006 DOI： 10.1515/BC.2004.051
Source DB: PubMed Journal: Biol Chem ISSN： 1431-6730 Impact factor: 3.915