Literature DB >> 15195925

RNA interference as an antiviral approach: targeting HIV-1.

Ben Berkhout1.   

Abstract

RNA interference (RNAi) is an evolutionary conserved gene-silencing mechanism in which 21- to 23-mer double-stranded short interfering RNA (siRNA) mediates the sequence-specific degradation of mRNA. The recent discovery that exogenously delivered siRNA can trigger RNAi in mammalian cells raises the possibility of using this technology as a therapeutic tool against pathogenic viruses. This review describes the antiviral RNAi field, which is barely two years-old, with an emphasis on recent studies aimed at suppression of HIV-1.

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Year:  2004        PMID： 15195925

Source DB:  PubMed          Journal:  Curr Opin Mol Ther        ISSN： 1464-8431


  29 in total

1.  Computational design of antiviral RNA interference strategies that resist human immunodeficiency virus escape.

Authors:  Joshua N Leonard; David V Schaffer
Journal:  J Virol       Date:  2005-02       Impact factor: 5.103

2.  The impact of unprotected T cells in RNAi-based gene therapy for HIV-AIDS.

Authors:  Elena Herrera-Carrillo; Ying Poi Liu; Ben Berkhout
Journal:  Mol Ther       Date:  2013-12-12       Impact factor: 11.454

Review 3.  Selection of RNAi-based inhibitors for anti-HIV gene therapy.

Authors:  Stefanie A Knoepfel; Mireille Centlivre; Ying Poi Liu; Fatima Boutimah; Ben Berkhout
Journal:  World J Virol       Date:  2012-06-12

4.  Inhibition of HIV-1 by a Lentiviral Vector with a Novel Tat-Inducible Expression System and a Specific Tropism to the Target Cells.

Authors:  Touraj Farazmandfar; Mohammad Reza Haghshenas; Majid Shahbazi
Journal:  Hum Gene Ther       Date:  2015-08-06       Impact factor: 5.695

5.  Newly designed six-membered azasugar nucleotide-containing phosphorothioate oligonucleotides as potent human immunodeficiency virus type 1 inhibitors.

Authors:  Dong-Seong Lee; Kyeong-Eun Jung; Cheol-Hee Yoon; Hong Lim; Yong-Soo Bae
Journal:  Antimicrob Agents Chemother       Date:  2005-10       Impact factor: 5.191

6.  Preclinical evaluation of an anti-HCV miRNA cluster for treatment of HCV infection.

Authors:  Xiao Yang; Katherine Marcucci; Xavier Anguela; Linda B Couto
Journal:  Mol Ther       Date:  2013-01-08       Impact factor: 11.454

7.  Possible applications for replicating HIV 1 vectors.

Authors:  Atze T Das; Rienk E Jeeninga; Ben Berkhout
Journal:  HIV Ther       Date:  2010-05-01

8.  Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions.

Authors:  V Valiunas; Y Y Polosina; H Miller; I A Potapova; L Valiuniene; S Doronin; R T Mathias; R B Robinson; M R Rosen; I S Cohen; P R Brink
Journal:  J Physiol       Date:  2005-07-21       Impact factor: 5.182

9.  Selection of potent non-toxic inhibitory sequences from a randomized HIV-1 specific lentiviral short hairpin RNA library.

Authors:  Carola Pongratz; Benjamin Yazdanpanah; Hamid Kashkar; Maik J Lehmann; Hans-Georg Kräusslich; Martin Krönke
Journal:  PLoS One       Date:  2010-10-08       Impact factor: 3.240

10.  A novel approach for inhibition of HIV-1 by RNA interference: counteracting viral escape with a second generation of siRNAs.

Authors:  Olivier ter Brake; Ben Berkhout
Journal:  J RNAi Gene Silencing       Date:  2005-10-14
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