Literature DB >> 15194874

Analysis of the expression, localization and activity of rat casein kinase 1epsilon-3.

Atsuko Takano1, Hyang-Sook Hoe, Yasushi Isojima, Katsuya Nagai.   

Abstract

Casein kinase 1epsilon (CK1epsilon) is a serine/threonine protein kinase that has been suggested to participate in the regulation of various signaling pathways. In this report, we examined the tissue distributions of three putative alternatively spliced forms of rCk1epsilon by RT-PCR. This analysis confirmed that all three isoforms are expressed in rat tissues with different tissue-specific expression patterns. Immunohistochemical analysis showed that the intracellular distribution of rCK1epsilon-3 in neurons was broader than that of rCK1epsilon-1. Moreover, the kinase activity of the rCK1epsilon-3 protein differed from that of rCK1epsilon-1. These data suggest that rCK1epsilon-1 and rCK1epsilon-3 may play different functional roles.

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Year:  2004        PMID： 15194874     DOI： 10.1097/01.wnr.0000133297.77278.81

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  6 in total

1.  Endogenous casein kinase-1 modulates NMDA receptor activity of hypothalamic presympathetic neurons and sympathetic outflow in hypertension.

Authors:  De-Pei Li; Jing-Jing Zhou; Hui-Lin Pan
Journal:  J Physiol       Date:  2015-08-18       Impact factor: 5.182

2.  Analysis of cell type-specific expression of CK1 epsilon in various tissues of young adult BALB/c Mice and in mammary tumors of SV40 T-Ag-transgenic mice.

Authors:  Anja C Utz; Heidrun Hirner; Annette Blatz; Andreas Hillenbrand; Bernhard Schmidt; Wolfgang Deppert; Doris Henne-Bruns; Dietmar Fischer; Dietmar R Thal; Frank Leithäuser; Uwe Knippschild
Journal:  J Histochem Cytochem       Date:  2009-09-15       Impact factor: 2.479

Review 3.  Coordinated regulation of circadian rhythms and homeostasis by the suprachiasmatic nucleus.

Authors:  Hachiro Nakagawa; Nobuaki Okumura
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2010       Impact factor: 3.493

4.  DARPP-32 is a robust integrator of dopamine and glutamate signals.

Authors:  Eric Fernandez; Renaud Schiappa; Jean-Antoine Girault; Nicolas Le Novère
Journal:  PLoS Comput Biol       Date:  2006-11-06       Impact factor: 4.475

5.  Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice.

Authors:  Jürgen Löhler; Heidrun Hirner; Bernhard Schmidt; Klaus Kramer; Dietmar Fischer; Dietmar R Thal; Frank Leithäuser; Uwe Knippschild
Journal:  PLoS One       Date:  2009-01-12       Impact factor: 3.240

6.  CK1δ kinase activity is modulated by Chk1-mediated phosphorylation.

Authors:  Joachim Bischof; Sven-Jannis Randoll; Nadine Süßner; Doris Henne-Bruns; Lorenzo A Pinna; Uwe Knippschild
Journal:  PLoS One       Date:  2013-07-04       Impact factor: 3.240
  6 in total

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