Literature DB >> 15194806

Ex vivo phenotype and frequency of influenza virus-specific CD4 memory T cells.

Michaela Lucas1, Cheryl L Day, Jessica R Wyer, Sharon L Cunliffe, Andrew Loughry, Andrew J McMichael, Paul Klenerman.   

Abstract

Recent advances in class II tetramer staining technology have allowed reliable direct ex vivo visualization of antigen-specific CD4 T cells. In order to define the frequency and phenotype of a prototype response to a nonpersistent pathogen, we have used such techniques to analyze influenza virus-specific memory CD4 T cells directly from blood. These responses are stably detectable ex vivo at low frequencies (range, 0.00012 to 0.0061% of CD4 T cells) and display a distinct "central memory" CD62L(+) phenotype.

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Year:  2004        PMID： 15194806      PMCID： PMC421690          DOI： 10.1128/JVI.78.13.7284-7287.2004

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  22 in total

1.  MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen.

Authors:  E J Novak; A W Liu; G T Nepom; W W Kwok
Journal:  J Clin Invest       Date:  1999-12       Impact factor: 14.808

2.  The arrival of HLA class II tetramers.

Authors:  A J McMichael; A Kelleher
Journal:  J Clin Invest       Date:  1999-12       Impact factor: 14.808

3.  Two subsets of memory T lymphocytes with distinct homing potentials and effector functions.

Authors:  F Sallusto; D Lenig; R Förster; M Lipp; A Lanzavecchia
Journal:  Nature       Date:  1999-10-14       Impact factor: 49.962

Review 4.  Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells.

Authors:  A Lanzavecchia; F Sallusto
Journal:  Science       Date:  2000-10-06       Impact factor: 47.728

5.  CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes.

Authors:  Edith M Janssen; Edward E Lemmens; Tom Wolfe; Urs Christen; Matthias G von Herrath; Stephen P Schoenberger
Journal:  Nature       Date:  2003-02-09       Impact factor: 49.962

6.  Optimization of peptide linker length in production of MHC class II/peptide tetrameric complexes increases yield and stability, and allows identification of antigen-specific CD4+T cells in peripheral blood mononuclear cells.

Authors:  Sharon L Cunliffe; Jessica R Wyer; Julian K Sutton; Michaela Lucas; Gillian Harcourt; Paul Klenerman; Andrew J McMichael; Anthony D Kelleher
Journal:  Eur J Immunol       Date:  2002-12       Impact factor: 5.532

7.  Lineage relationship and protective immunity of memory CD8 T cell subsets.

Authors:  E John Wherry; Volker Teichgräber; Todd C Becker; David Masopust; Susan M Kaech; Rustom Antia; Ulrich H von Andrian; Rafi Ahmed
Journal:  Nat Immunol       Date:  2003-02-03       Impact factor: 25.606

8.  Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections.

Authors:  Victor Appay; P Rod Dunbar; Margaret Callan; Paul Klenerman; Geraldine M A Gillespie; Laura Papagno; Graham S Ogg; Abigail King; Franziska Lechner; Celsa A Spina; Susan Little; Diane V Havlir; Douglas D Richman; Norbert Gruener; Gerd Pape; Anele Waters; Philippa Easterbrook; Mariolina Salio; Vincenzo Cerundolo; Andrew J McMichael; Sarah L Rowland-Jones
Journal:  Nat Med       Date:  2002-04       Impact factor: 53.440

9.  Viral immune evasion due to persistence of activated T cells without effector function.

Authors:  A J Zajac; J N Blattman; K Murali-Krishna; D J Sourdive; M Suresh; J D Altman; R Ahmed
Journal:  J Exp Med       Date:  1998-12-21       Impact factor: 14.307

10.  CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function.

Authors:  Eulogia Román; Ellen Miller; Allen Harmsen; James Wiley; Ulrich H Von Andrian; Gail Huston; Susan L Swain
Journal:  J Exp Med       Date:  2002-10-07       Impact factor: 14.307
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  38 in total

Review 1.  The physiological role of cytotoxic CD4(+) T-cells: the holy grail?

Authors:  V Appay
Journal:  Clin Exp Immunol       Date:  2004-10       Impact factor: 4.330

2.  Transient immunological control during acute hepatitis C virus infection: ex vivo analysis of helper T-cell responses.

Authors:  A Ulsenheimer; M Lucas; N P Seth; J Tilman Gerlach; N H Gruener; A Loughry; G R Pape; K W Wucherpfennig; H M Diepolder; P Klenerman
Journal:  J Viral Hepat       Date:  2006-10       Impact factor: 3.728

Review 3.  Class II major histocompatibility complex tetramer staining: progress, problems, and prospects.

Authors:  Sabrina S Vollers; Lawrence J Stern
Journal:  Immunology       Date:  2008-03       Impact factor: 7.397

4.  The alveolar immune cell landscape is dysregulated in checkpoint inhibitor pneumonitis.

Authors:  Karthik Suresh; Jarushka Naidoo; Qiong Zhong; Ye Xiong; Jennifer Mammen; Marcia Villegas de Flores; Laura Cappelli; Aanika Balaji; Tsvi Palmer; Patrick M Forde; Valsamo Anagnostou; David S Ettinger; Kristen A Marrone; Ronan J Kelly; Christine L Hann; Benjamin Levy; Josephine L Feliciano; Cheng-Ting Lin; David Feller-Kopman; Andrew D Lerner; Hans Lee; Majid Shafiq; Lonny Yarmus; Evan J Lipson; Mark Soloski; Julie R Brahmer; Sonye K Danoff; Franco D'Alessio
Journal:  J Clin Invest       Date:  2019-07-16       Impact factor: 14.808

Review 5.  MHC class II tetramers.

Authors:  Gerald T Nepom
Journal:  J Immunol       Date:  2012-03-15       Impact factor: 5.422

6.  HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral rebound.

Authors:  Thomas J Scriba; Hua-Tang Zhang; Helen L Brown; Annette Oxenius; Norbert Tamm; Sarah Fidler; Julie Fox; Jonathan N Weber; Paul Klenerman; Cheryl L Day; Michaela Lucas; Rodney E Phillips
Journal:  J Clin Invest       Date:  2005-02       Impact factor: 14.808

Review 7.  Generation and maintenance of human memory cells during viral infection.

Authors:  Rabih Halwani; Mehrnoosh Doroudchi; Bader Yassine-Diab; Loury Janbazian; Yu Shi; Elias A Said; Elias K Haddad; Rafick-Pierre Sékaly
Journal:  Springer Semin Immunopathol       Date:  2006-09-12

8.  The anthrax vaccine adsorbed vaccine generates protective antigen (PA)-Specific CD4+ T cells with a phenotype distinct from that of naive PA T cells.

Authors:  William W Kwok; Junbao Yang; Eddie James; John Bui; Laurie Huston; Andrew R Wiesen; Michelle Roti
Journal:  Infect Immun       Date:  2008-08-04       Impact factor: 3.441

9.  Varicella zoster virus glycoprotein E-specific CD4+ T cells show evidence of recent activation and effector differentiation, consistent with frequent exposure to replicative cycle antigens in healthy immune donors.

Authors:  G N Malavige; L Jones; A P Black; G S Ogg
Journal:  Clin Exp Immunol       Date:  2008-03-20       Impact factor: 4.330

10.  Tracking epitope-specific T cells.

Authors:  James J Moon; H Hamlet Chu; Jason Hataye; Antonio J Pagán; Marion Pepper; James B McLachlan; Traci Zell; Marc K Jenkins
Journal:  Nat Protoc       Date:  2009       Impact factor: 13.491
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