| Literature DB >> 15194218 |
Hiroaki Toshimitsu1, Kiichiro Hashimoto, Akira Tangoku, Norio Iizuka, Kohtaro Yamamoto, Shigeto Kawauchi, Atsunori Oga, Tomoko Furuya, Masaaki Oka, Kohsuke Sasaki.
Abstract
To clarify the molecular basis of acquired cisplatin (CDDP) resistance in esophageal squamous cell carcinoma (ESCC), we used cDNA microarray technology. A CDDP-resistant cell line (YES-2/CDDP), which shows a 7.5-fold increase in resistance to CDDP and a 3-fold decrease in CDDP accumulation compared with the parental YES-2 ESCC cell line, was generated from YES-2 by exposure to increased concentrations of CDDP. By cDNA microarray analysis, we identified 44 genes with significantly different expression levels between YES-2/CDDP and YES-2 cells. Interestingly, 15 of these 44 genes encoded ribosome-related proteins, almost all of which were underexpressed in YES-2/CDDP cells. Our present data suggest that many ribosome-related genes may be involved in the acquired resistance to CDDP in ESCC and that such information may allow us to better understand the mechanism of CDDP resistance. Copyright 2004 Elsevier Ireland Ltd.Entities:
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Year: 2004 PMID： 15194218 DOI： 10.1016/j.canlet.2004.01.038
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679