| Literature DB >> 15193448 |
Juan Ramón González García1, Stefan K Bohlander, Melva Gutiérrez Angulo, María Amparo Esparza Flores, Verónica Judith Picos Cárdenas, Juan Pablo Meza Espinoza, María de la Luz Ayala Madrigal, Horacio Rivera.
Abstract
Recurring chromosome translocations, which are found in leukemia, can result in the inappropriate expression of oncogenes or in the formation of chimeric genes that code for structurally and functionally abnormal proteins. The chromosomal t(1;9)(q23.3 approximately q25;q34) was found in a patient with biphenotypic leukemia. Fluorescence in situ hybridization (FISH) analysis revealed that the break on chromosome 9 occurred in the ABL1 gene. The breakpoint on chromosome 1 occurred distal to the PBX1 gene at 1q23.3, as shown by FISH using BAC RP11-503N16 and RP11-403P14, which flank the PBX1 locus; hence, the ABL1 gene can be fused with another gene distal to PBX1 gene.Entities:
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Year: 2004 PMID： 15193448 DOI： 10.1016/j.cancergencyto.2003.10.014
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608