BACKGROUND: Pituitary prolactinoma containing spherical amyloid is rare. Squash smear findings of spherical amyloid in pituitary prolactinoma are characteristic. CASE: A 25-year-old woman presented with a pituitary tumor. The intraoperative squash smear showed abundant, homogeneous, eosinophilic material with multiple prominent striations. The scattered atypical cells in the periphery contained an irregular, bizarre nucleus; coarse chromatin; occasional prominent nucleoli; rare cytoplasm; and prolactin immunoreactivity. CONCLUSION: The characteristic squash smear findings should be helpful in the diagnosis of this rare tumor.
BACKGROUND:Pituitary prolactinoma containing spherical amyloid is rare. Squash smear findings of spherical amyloid in pituitary prolactinoma are characteristic. CASE: A 25-year-old woman presented with a pituitary tumor. The intraoperative squash smear showed abundant, homogeneous, eosinophilic material with multiple prominent striations. The scattered atypical cells in the periphery contained an irregular, bizarre nucleus; coarse chromatin; occasional prominent nucleoli; rare cytoplasm; and prolactin immunoreactivity. CONCLUSION: The characteristic squash smear findings should be helpful in the diagnosis of this rare tumor.
Authors: Sherwin Tavakol; Asma Hasan; Michelle A Wedemeyer; Joshua Bakhsheshian; Chia-Shang J Liu; Mark S Shiroishi; Anna Mathew; John D Carmichael; Gabriel Zada Journal: J Neurol Surg B Skull Base Date: 2019-02-05