BACKGROUND: Population-based studies have documented an association between obesity and an increased prevalence of asthma in women. METHODS: We prospectively studied 58 obese women with a body mass index of > 30 kg/m(2), 24 of whom had asthma, who were enrolled in an intensive 6-month weight loss program to determine whether loss of body mass would be correlated with improvements in bronchial reactivity, lung function, and disease-specific health status. RESULTS: Patients lost an average of 20 kg over the 6-month period. For every 10% relative loss of weight, the FVC improved by 92 mL (p = 0.05) and the FEV(1) improved by 73 mL (p = 0.04), however, bronchial reactivity did not significantly change with weight loss (p = 0.23). Patients who lost > 13% of their pretreatment weight experienced improvements in FEV(1) (p = 0.01), FVC (p = 0.02), and total lung capacity (p = 0.05) compared to patients in the lowest quartile who failed to lose significant amounts of weight. Neither group experienced any significant change in methacholine responsiveness (p = 0.57). Patients who completed the 6-month weight loss program experienced improvements in respiratory health status, irrespective of weight loss. CONCLUSION: We concluded that weight loss can improve lung function in obese women, however, the improvements appear to be independent of changes in airway reactivity.
BACKGROUND: Population-based studies have documented an association between obesity and an increased prevalence of asthma in women. METHODS: We prospectively studied 58 obesewomen with a body mass index of > 30 kg/m(2), 24 of whom had asthma, who were enrolled in an intensive 6-month weight loss program to determine whether loss of body mass would be correlated with improvements in bronchial reactivity, lung function, and disease-specific health status. RESULTS:Patients lost an average of 20 kg over the 6-month period. For every 10% relative loss of weight, the FVC improved by 92 mL (p = 0.05) and the FEV(1) improved by 73 mL (p = 0.04), however, bronchial reactivity did not significantly change with weight loss (p = 0.23). Patients who lost > 13% of their pretreatment weight experienced improvements in FEV(1) (p = 0.01), FVC (p = 0.02), and total lung capacity (p = 0.05) compared to patients in the lowest quartile who failed to lose significant amounts of weight. Neither group experienced any significant change in methacholine responsiveness (p = 0.57). Patients who completed the 6-month weight loss program experienced improvements in respiratory health status, irrespective of weight loss. CONCLUSION: We concluded that weight loss can improve lung function in obesewomen, however, the improvements appear to be independent of changes in airway reactivity.
Authors: James B Johnson; Warren Summer; Roy G Cutler; Bronwen Martin; Dong-Hoon Hyun; Vishwa D Dixit; Michelle Pearson; Matthew Nassar; Richard Telljohann; Richard Tellejohan; Stuart Maudsley; Olga Carlson; Sujit John; Donald R Laub; Mark P Mattson Journal: Free Radic Biol Med Date: 2006-12-14 Impact factor: 7.376
Authors: Talea Cornelius; Joseph E Schwartz; Pallavi Balte; Surya P Bhatt; Patricia A Cassano; David Currow; David R Jacobs; Miriam Johnson; Ravi Kalhan; Richard Kronmal; Laura Loehr; George T O'Connor; Benjamin Smith; Wendy B White; Sachin Yende; Elizabeth C Oelsner Journal: Am J Epidemiol Date: 2020-10-01 Impact factor: 4.897