| Literature DB >> 15186853 |
Jin Sung Kim1, Hyun-Jung Lee, Myung-Eun Suh, Hea-Young Park Choo, Sang Kook Lee, Hyen Joo Park, Choonmi Kim, Sang Woo Park, Chong-Ock Lee.
Abstract
A series of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives 8 was synthesized from 6,7-dichlorophthalazine-5,8-dione 5 and evaluated for in vitro cytotoxicity against several human tumor cell lines. Most of the tested compounds showed potential cytotoxic activity considerably higher than that of the reference compounds, ellipticine and doxorubicin.Entities:
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Year: 2004 PMID： 15186853 DOI： 10.1016/j.bmc.2004.04.014
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641