Literature DB >> 15186850

Synthesis and antitumor activity of 20-O-linked nitrogen-based camptothecin ester derivatives.

Cun-ying Wang1, Xian-dao Pan, Hong-yan Liu, Zhao-di Fu, Xian-yong Wei, Li-Xi Yang.   

Abstract

A series of nitrogen-based 20S-hydroxyl camptothecin ester derivatives were prepared. 3-Aminopropionate of camptothecin was found more cytotoxic in vitro on several human tumor cell lines than 3-amidopropionate of camptothecin. Ester 16 showed best antitumor activity in vivo and in vitro in all esters we prepared.

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Year:  2004        PMID： 15186850     DOI： 10.1016/j.bmc.2004.04.023

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

1.  Mitochondria-targetable ratiometric fluorescence probe for carbon monoxide based on naphthalimide derivatives.

Authors:  Fangkai Du; Yunting Qu; Mengru Li; Xuecai Tan
Journal:  Anal Bioanal Chem       Date:  2021-01-06       Impact factor: 4.142

Review 2.  Perspectives on biologically active camptothecin derivatives.

Authors:  Ying-Qian Liu; Wen-Qun Li; Susan L Morris-Natschke; Keduo Qian; Liu Yang; Gao-Xiang Zhu; Xiao-Bing Wu; An-Liang Chen; Shao-Yong Zhang; Xiang Nan; Kuo-Hsiung Lee
Journal:  Med Res Rev       Date:  2015-03-21       Impact factor: 12.944

3.  Comparison of two self-assembled macromolecular prodrug micelles with different conjugate positions of SN38 for enhancing antitumor activity.

Authors:  Yi Liu; Hongyu Piao; Ying Gao; Caihong Xu; Ye Tian; Lihong Wang; Jinwen Liu; Bo Tang; Meijuan Zou; Gang Cheng
Journal:  Int J Nanomedicine       Date:  2015-03-23

4.  A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative.

Authors:  Changkuo Zhao; Xianheng Wang; Fuhong Yang; Lei Gao; Yuhe Wang
Journal:  R Soc Open Sci       Date:  2018-02-14       Impact factor: 2.963
  4 in total

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