| Literature DB >> 15186846 |
Sandrine Ropp1, Julia Guy, Valérie Berl, Pierre Bischoff, Jean-Pierre Lepoittevin.
Abstract
The synthesis of a new alpha-methylene-gamma-butyrolactone-psoralen heterodimer 2 is reported. Its photoantiproliferative activity and skin phototoxicity were compared with that of 5-methoxypsoralen (5-MOP) and another heterodimer 1. Both derivatives show a significant phototoxicity toward malignant cell lines including melanoma cells A375 compared to their intrinsic cytotoxicity in the dark. Both compounds were found to be nonphototoxic on mice skin and therefore could be active potential drugs in photochemotherapy.Entities:
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Year: 2004 PMID： 15186846 DOI： 10.1016/j.bmc.2004.04.019
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641