| Literature DB >> 15186839 |
Csaba Csutoras1, Ao Zhang, Kehong Zhang, Nora S Kula, Ross J Baldessarini, John L Neumeyer.
Abstract
We synthesized several N-substituted-11-hydroxynoraporphines and their esters of varying chain length, evaluated their binding affinity at dopamine (DA) receptor sites in rat caudate-putamen membranes, and quantified their effects on motor activity in normal adult male rats. The 11-hydroxyaporphines showed similar neuropharmacological properties to the corresponding 10,11-catecholaporphines. At moderate doses, their esters proved to have more prolonged behavioral actions and superior oral bioavailability.Entities:
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Year: 2004 PMID： 15186839 DOI： 10.1016/j.bmc.2004.04.029
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641